Poly (A)-binding proteins: multifunctional scaffolds for the post-transcriptional control of gene expression
DA Mangus, MC Evans, A Jacobson - Genome biology, 2003 - Springer
Most eukaryotic mRNAs are subject to considerable post-transcriptional modification,
including capping, splicing, and polyadenylation. The process of polyadenylation adds a …
including capping, splicing, and polyadenylation. The process of polyadenylation adds a …
Control of poly (A) tail length
CR Eckmann, C Rammelt… - Wiley Interdisciplinary …, 2011 - Wiley Online Library
Poly (A) tails have long been known as stable 3′ modifications of eukaryotic mRNAs,
added during nuclear pre‐mRNA processing. It is now appreciated that this modification is …
added during nuclear pre‐mRNA processing. It is now appreciated that this modification is …
Polyadenylation and nuclear export of mRNAs
M Stewart - Journal of Biological Chemistry, 2019 - ASBMB
In eukaryotes, the separation of translation from transcription by the nuclear envelope
enables mRNA modifications such as capping, splicing, and polyadenylation. These …
enables mRNA modifications such as capping, splicing, and polyadenylation. These …
Protein factors in pre-mRNA 3′-end processing
CR Mandel, Y Bai, L Tong - Cellular and Molecular Life Sciences, 2008 - Springer
Most eukaryotic mRNA precursors (premRNAs) must undergo extensive processing,
including cleavage and polyadenylation at the 3′-end. Processing at the 3′-end is …
including cleavage and polyadenylation at the 3′-end. Processing at the 3′-end is …
Architecture of eukaryotic mRNA 3′-end processing machinery
Newly transcribed eukaryotic precursor messenger RNAs (pre-mRNAs) are processed at
their 3′ ends by the~ 1-megadalton multiprotein cleavage and polyadenylation factor …
their 3′ ends by the~ 1-megadalton multiprotein cleavage and polyadenylation factor …
Human Fip1 is a subunit of CPSF that binds to U‐rich RNA elements and stimulates poly (A) polymerase
I Kaufmann, G Martin, A Friedlein, H Langen… - The EMBO …, 2004 - embopress.org
In mammals, polyadenylation of mRNA precursors (pre‐mRNAs) by poly (A) polymerase
(PAP) depends on cleavage and polyadenylation specificity factor (CPSF). CPSF is a …
(PAP) depends on cleavage and polyadenylation specificity factor (CPSF). CPSF is a …
[HTML][HTML] Symplekin and xGLD-2 are required for CPEB-mediated cytoplasmic polyadenylation
Cytoplasmic polyadenylation-induced mRNA translation is a hallmark of early animal
development. In Xenopus oocytes, where the molecular mechanism has been defined, the …
development. In Xenopus oocytes, where the molecular mechanism has been defined, the …
The FIP1L1-PDGFRα fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: implications for diagnosis, classification, and …
J Gotlib, J Cools, JM Malone III, SL Schrier… - Blood, 2004 - ashpublications.org
Idiopathic hypereosinophilic syndrome (HES) and chronic eosinophilic leukemia (CEL)
comprise a spectrum of indolent to aggressive diseases characterized by unexplained …
comprise a spectrum of indolent to aggressive diseases characterized by unexplained …
Organization and function of APT, a subcomplex of the yeast cleavage and polyadenylation factor involved in the formation of mRNA and small nucleolar RNA 3 …
Messenger RNA 3′-end formation is functionally coupled to transcription by RNA
polymerase II. By tagging and purifying Ref2, a non-essential protein previously implicated …
polymerase II. By tagging and purifying Ref2, a non-essential protein previously implicated …
Therapeutic targeting of CPSF3-dependent transcriptional termination in ovarian cancer
P Shen, K Ye, H Xiang, Z Zhang, Q He, X Zhang… - Science …, 2023 - science.org
Transcriptional dysregulation is a recurring pathogenic hallmark and an emerging
therapeutic vulnerability in ovarian cancer. Here, we demonstrated that ovarian cancer …
therapeutic vulnerability in ovarian cancer. Here, we demonstrated that ovarian cancer …