The organic cation transporters (OCTs) OCT1, OCT2, OCT3, novel OCT (OCTN) 1, OCTN2,
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …

In arbitrary dimension, in the discrete setting of finite-differences we prove a Carleman
estimate for a semi-discrete parabolic operator, in which the large parameter is connected to …

Summary Background Pre-exposure prophylaxis (PrEP) with oral emtricitabine and tenofovir
disoproxil fumarate is used to prevent the sexual acquisition of HIV in groups at high risk …

The SLC22 family contains 13 functionally characterized human plasma membrane proteins
each with 12 predicted α-helical transmembrane domains. The family comprises organic …

Transporters in proximal renal tubules contribute to the disposition of numerous drugs.
Furthermore, the molecular mechanisms of tubular secretion have been progressively …

Introduction Globally, transgender (“trans”) women are one of the key populations most
disproportionately impacted by HIV. Pre‐exposure prophylaxis (PrEP) is the newest and …

Introduction: Organic cation transporters collectively called OCTs belong to three gene
families (SLC22A1 OCT1, SLC22A2 OCT2, SLC22A3 OCT3, SLC22A4 OCTN1, SLC22A5 …

Pyrimidine and purine nucleosides and their derivatives have critical functions and
pharmacological applications in the brain. Nucleosides and nucleobases are precursors of …

Extracellular adenosine concentrations are regulated by a panel of membrane transporters
which, in most cases, mediate its uptake into cells. Adenosine transporters belong to two …

Nucleoside and nucleobase analogs are currently used in the treatment of solid tumors,
lymphoproliferative diseases, viral infections such as hepatitis and AIDS, and some …