Endothelial dysfunction is a well established response to cardiovascular risk factors and
precedes the development of atherosclerosis. Endothelial dysfunction is involved in lesion …

Diabetes mellitus is associated with an increased risk of cardiovascular disease, even in the
presence of intensive glycemic control. Substantial clinical and experimental evidence …

The aim of the present study was to compare different diets used to induce obesity in a head-
to-head manner with a focus on insulin resistance and vascular dysfunction. Male C57BL/6J …

Sleep-disordered breathing is a prevalent condition associated with impairment of daytime
function and may predispose individuals to metabolic abnormalities independent of obesity …

The main etiology for mortality and a great percent of morbidity in patients with diabetes
mellitus is atherosclerosis. A hypothesis for the initial lesion of atherosclerosis is endothelial …

Summary Plasminogen activator inhibitor‐1 (PAI‐1) is the major physiologic inhibitor of
tissue‐type plasminogen activator in plasma, and is elevated in a variety of clinical situations …

Diabetes mellitus is characterized by a high risk of atherothrombotic events. What is more,
venous thrombosis has also been found to occur more frequently in this patient group. This …

Diabetes mellitus (DM) is characterized by fasting hyperglycaemia and a high risk of
atherothrombotic disorders affecting the coronary, cerebral and peripheral arterial trees. The …

The urokinase plasminogen activator (uPA) system (uPAS) consists of the uPA, its cognate
receptor (uPAR) and two specific inhibitors, the plasminogen activator inhibitor 1 (PAI-1) and …

Elevated plasma plasminogen activator inhibitor-1 (PAI-1) level is a core feature of insulin-
resistance syndrome (IRS). Atherothrombotic complications in IRS are partly attributed to …