Molecular mechanisms of colon cancer progression and metastasis: recent insights and advancements
Colorectal cancer (CRC), the third most common type of cancer, is the second leading cause
of cancer-related mortality rates worldwide. Although modern research was able to shed …
of cancer-related mortality rates worldwide. Although modern research was able to shed …
Biomarker-guided therapy for colorectal cancer: strength in complexity
The number of molecularly stratified treatment options available to patients with colorectal
cancer (CRC) is increasing, with a parallel rise in the use of biomarkers to guide …
cancer (CRC) is increasing, with a parallel rise in the use of biomarkers to guide …
[HTML][HTML] The current understanding on the impact of KRAS on colorectal cancer
M Meng, K Zhong, T Jiang, Z Liu, HY Kwan… - Biomedicine & …, 2021 - Elsevier
KRAS (kirsten rat sarcoma viral oncogene) is a member of the RAS family. KRAS mutations
are one of most dominant mutations in colorectal cancer (CRC). The impact of KRAS …
are one of most dominant mutations in colorectal cancer (CRC). The impact of KRAS …
Temozolomide treatment alters mismatch repair and boosts mutational burden in tumor and blood of colorectal cancer patients
The majority of metastatic colorectal cancers (mCRC) are mismatch repair (MMR) proficient
and unresponsive to immunotherapy, whereas MMR-deficient (MMRd) tumors often respond …
and unresponsive to immunotherapy, whereas MMR-deficient (MMRd) tumors often respond …
The Evolutionary Landscape of Treatment for BRAFV600E Mutant Metastatic Colorectal Cancer
Simple Summary The BRAFV600E mutation accounts for 8–10% of metastatic colorectal
cancer (mCRC) patients and it is an established prognostic factor. Median overall survival of …
cancer (mCRC) patients and it is an established prognostic factor. Median overall survival of …
The heterogeneous clinical and pathological landscapes of metastatic Braf-mutated colorectal cancer
GN Fanelli, CA Dal Pozzo, I Depetris, M Schirripa… - Cancer Cell …, 2020 - Springer
Colorectal cancer (CRC) is a complex and molecularly heterogeneous disease representing
one of the most frequent causes of cancer-related death worldwide. About 8–15% of CRCs …
one of the most frequent causes of cancer-related death worldwide. About 8–15% of CRCs …
Is hepatectomy justified for BRAF mutant colorectal liver metastases?: a multi-institutional analysis of 1497 patients
Objective: To analyze clinical outcomes and prognostic variables of patients undergoing
hepatic resection for BRAF mutant (BRAF-mut) colorectal liver metastases (CRLM) …
hepatic resection for BRAF mutant (BRAF-mut) colorectal liver metastases (CRLM) …
Prognostic and predictive molecular biomarkers in advanced colorectal cancer
V Martelli, A Pastorino, AF Sobrero - Pharmacology & Therapeutics, 2022 - Elsevier
The revolution of precision medicine has produced unprecedented seismic shifts in the
treatment paradigm of advanced cancers. Among the major killers, colorectal cancer (CRC) …
treatment paradigm of advanced cancers. Among the major killers, colorectal cancer (CRC) …
Carcinogenesis and reactive oxygen species signaling: Interaction of the NADPH oxidase NOX1–5 and superoxide dismutase 1–3 signal transduction pathways
A Parascandolo, MO Laukkanen - Antioxidants & redox signaling, 2019 - liebertpub.com
Abstract Significance: Reduction/oxidation (redox) balance could be defined as an even
distribution of reduction and oxidation complementary processes and their reaction end …
distribution of reduction and oxidation complementary processes and their reaction end …
[HTML][HTML] Methods and biomarkers for early detection, prediction, and diagnosis of colorectal cancer
Y Zhang, Y Wang, B Zhang, P Li, Y Zhao - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Colorectal cancer (CRC) is one of the most common digestive diseases worldwide. It has
steadily ascended to the top three cancers in terms of incidence and mortality. The primary …
steadily ascended to the top three cancers in terms of incidence and mortality. The primary …