Cardiovascular diseases are the most prominent maladies in aging societies. Indeed, aging
promotes the structural and functional declines of both the heart and the blood circulation …

Drosophila melanogaster has been a key model in developing our current understanding of
the molecular mechanisms of ageing. Of particular note is its role in establishing the …

Acetate is a major end product of bacterial fermentation of fiber in the gut. Acetate, whether
derived from the diet or from fermentation in the colon, has been implicated in a range of …

Several natural compounds found in health-related food items can inhibit acetyltransferases
as they induce autophagy. Here we show that this applies to anacardic acid, curcumin …

Eukaryotes initiate autophagy when facing environmental changes such as a lack of
external nutrients. However, the mechanisms of autophagy initiation are still not fully …

Abstract Acetyl-CoA synthetase 2 (ACSS2), an important member of the acetyl-CoA
synthetase (ACSS) family, can catalyze the conversion of acetate to acetyl coenzyme A …

Although advances in medical technology and health care have improved the early
diagnosis and management for cardiorenal metabolic disorders, the prevalence of obesity …

Diffuse large B cell lymphomas (DLBCLs) are genetically heterogeneous and highly
proliferative neoplasms derived from germinal center (GC) B cells. Here, we show that …

Metformin, a biguanide, is a widely used antidiabetic drug, which inhibits gluconeogenesis
and is used to treat hyperglycemia in type 2 diabetes. Through activation of AMPK (AMP …

In recent years, there has been a great deal of attention toward the molecular machinery
relevant to age-related progression controlled through the external intervention of …