Writers and readers of histone acetylation: structure, mechanism, and inhibition
R Marmorstein, MM Zhou - Cold Spring Harbor …, 2014 - cshperspectives.cshlp.org
Histone acetylation marks are written by histone acetyltransferases (HATs) and read by
bromodomains (BrDs), and less commonly by other protein modules. These proteins …
bromodomains (BrDs), and less commonly by other protein modules. These proteins …
Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor
EM Bowers, G Yan, C Mukherjee, A Orry, L Wang… - Chemistry & biology, 2010 - cell.com
The histone acetyltransferase (HAT) p300/CBP is a transcriptional coactivator implicated in
many gene regulatory pathways and protein acetylation events. Although p300 inhibitors …
many gene regulatory pathways and protein acetylation events. Although p300 inhibitors …
The Mediator complex and transcription regulation
ZC Poss, CC Ebmeier, DJ Taatjes - Critical reviews in biochemistry …, 2013 - Taylor & Francis
The Mediator complex is a multi-subunit assembly that appears to be required for regulating
expression of most RNA polymerase II (pol II) transcripts, which include protein-coding and …
expression of most RNA polymerase II (pol II) transcripts, which include protein-coding and …
Signals and combinatorial functions of histone modifications
T Suganuma, JL Workman - Annual review of biochemistry, 2011 - annualreviews.org
Alterations of chromatin structure have been shown to be crucial for response to cell
signaling and for programmed gene expression in development. Posttranslational histone …
signaling and for programmed gene expression in development. Posttranslational histone …
CBP/p300-mediated acetylation of histone H3 on lysine 56
Acetylation within the globular core domain of histone H3 on lysine 56 (H3K56) has recently
been shown to have a critical role in packaging DNA into chromatin following DNA …
been shown to have a critical role in packaging DNA into chromatin following DNA …
Chemical mechanisms of histone lysine and arginine modifications
Histone lysine and arginine residues are subject to a wide array of post-translational
modifications including methylation, citrullination, acetylation, ubiquitination, and …
modifications including methylation, citrullination, acetylation, ubiquitination, and …
Screen for DNA‐damage‐responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells
JV Tjeertes, KM Miller, SP Jackson - The EMBO journal, 2009 - embopress.org
Recognition and repair of damaged DNA occurs within the context of chromatin. The key
protein components of chromatin are histones, whose post‐translational modifications …
protein components of chromatin are histones, whose post‐translational modifications …
Histone modifying enzymes: structures, mechanisms, and specificities
R Marmorstein, RC Trievel - Biochimica et Biophysica Acta (BBA)-Gene …, 2009 - Elsevier
Histone modifying enzymes catalyze the addition or removal of an array of covalent
modifications in histone and non-histone proteins. Within the context of chromatin, these …
modifications in histone and non-histone proteins. Within the context of chromatin, these …
Modular synthetic biology toolkit for filamentous fungi
Filamentous fungi are highly productive cell factories, often used in industry for the
production of enzymes and small bioactive compounds. Recent years have seen an …
production of enzymes and small bioactive compounds. Recent years have seen an …