A major event in embryonic development is the rearrangement of epigenetic information as
the somatic genome is reprogrammed for a new round of organismal development …

INTRODUCTION Cell differentiation is classically described as a unidirectional process that
progresses through a series of lineage restriction events, with cellular potential being …

The pluripotency of mammalian early and late epiblast could be recapitulated by naïve
embryonic stem cells (ESCs) and primed epiblast stem cells (EpiSCs), respectively …

Pioneer transcription factors (TFs), such as OCT4 and SOX2, play crucial roles in
pluripotency regulation. However, the master TF-governed pluripotency regulatory circuitry …

Neural crest cells are central to vertebrate development and evolution, endowing
vertebrates with a “new head” that resulted in morphological, physiological, and behavioral …

Background Enhancers are distal regulators of gene expression that shape cell identity and
control cell fate transitions. In mouse embryonic stem cells (mESCs), the pluripotency …

The circadian clock component NR1D1 (REVERBα) is considered a dominant regulator of
lipid metabolism, with global Nr1d1 deletion driving dysregulation of white adipose tissue …

Zinc finger protein with KRAB and SCAN domains 3 (ZKSCAN3) has long been known as a
master transcriptional repressor of autophagy. Here, we identify a novel role for ZKSCAN3 in …

Our understanding of pluripotency remains limited: iPSC generation has only been
established for a few model species, pluripotent stem cell lines exhibit inconsistent …

The nuclear receptor REVERBα is a core component of the circadian clock and proposed to
be a dominant regulator of hepatic lipid metabolism. Using antibody-independent ChIP …