Organismal ageing is accompanied by progressive loss of cellular function and systemic
deterioration of multiple tissues, leading to impaired function and increased vulnerability to …

Mitochondria were first postulated to contribute to aging more than 40 years ago. During the
following decades, multiple lines of evidence in model organisms and humans showed that …

Abstract (See the Editorial Commentary by Capeau, on pages 1127–9.) Background.
Human immunodeficiency virus (HIV)–infected patients may have a greater risk of …

Background. Antiretroviral therapy has reduced the incidence of adverse events and early
mortality in HIV-infected persons. Despite these benefits, important comorbidities that …

Nowadays, HIV+ patients have an expected lifespan that is only slightly shorter than healthy
individuals. For this reason, along with the fact that infection can be acquired at a relatively …

The age-related vasculature alteration is the prominent risk factor for vascular diseases
(VD), namely, atherosclerosis, abdominal aortic aneurysm, vascular calcification (VC) and …

Cardiovascular complications are more common in human immunodeficiency virus–infected
individuals than in age-matched uninfected individuals. Antiretroviral therapy reduces the …

Background Vascular age is an alternate means of representing an individual's
cardiovascular risk. Little consensus exists on what vascular age represents and its clinical …

There is emerging evidence that people with successfully treated HIV infection age
prematurely, leading to progressive multi-organ disease, but the reasons for this are not …

Background—HIV infection continues to be endemic worldwide. Although treatments are
successful, it remains controversial whether patients receiving optimal therapy have …