Objectives: Traumatic brain injury (TBI) precipitates a neuroinflammatory cascade, with the
NLRP3 inflammasome emerging as a critical mediator. This review scrutinizes the complex …

Pain is estimated to affect more than 20% of the global population, imposing incalculable
health and economic burdens. Effective pain management is crucial for individuals suffering …

Background The treatment of spinal cord injury (SCI) has always been a significant research
focus of clinical neuroscience, with inhibition of microglia-mediated neuro-inflammation as …

Inflammation during the perioperative period of joint arthroplasty is a critical aspect of patient
outcomes, influencing both the pathophysiology of pain and the healing process. This …

Background Methotrexate (MTX) is a classical folic acid antagonist widely used in the
treatment of malignant and non-malignant disorders. However, its clinical application is often …

This study employed transcriptome sequencing and targeted metabolomics to delve into the
molecular alterations in mouse spinal cords following spinal cord injury (SCI). Notably, a …

Болезнь Альцгеймера—одно из самых распространенных нейродегенеративных
заболеваний, которое ежегодно диагностируется впервые у более 1, 5 млн человек, а …

The study aimed to investigate the role of peripheral NLR family pyrin domain-containing 3
protein (NLRP3) in inflammatory pain development in the orofacial area. Male Sprague …

This study employed transcriptome sequencing and targeted metabolomics to delve into the
molecular alterations in mouse spinal cords following spinal cord injury (SCI). Notably, a …