HMGB1 in health and disease
R Kang, R Chen, Q Zhang, W Hou, S Wu, L Cao… - Molecular aspects of …, 2014 - Elsevier
Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …
emergence of chromosomal instability, development of unscheduled cell death, skewed …
An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies
Abstract HMGB1 (High-Mobility Group Box-1) is a nuclear protein that acts as an
architectural chromatin-binding factor involved in the maintenance of nucleosome structure …
architectural chromatin-binding factor involved in the maintenance of nucleosome structure …
HMGB proteins: interactions with DNA and chromatin
M Štros - Biochimica et Biophysica Acta (BBA)-Gene Regulatory …, 2010 - Elsevier
HMGB proteins are members of the High Mobility Group (HMG) superfamily, possessing a
unique DNA-binding domain, the HMG-box, which can bind non-B-type DNA structures …
unique DNA-binding domain, the HMG-box, which can bind non-B-type DNA structures …
High-mobility group box 1, oxidative stress, and disease
Oxidative stress and associated reactive oxygen species can modify lipids, proteins,
carbohydrates, and nucleic acids, and induce the mitochondrial permeability transition …
carbohydrates, and nucleic acids, and induce the mitochondrial permeability transition …
RAGE (Receptor for Advanced Glycation Endproducts), RAGE ligands, and their role in cancer and inflammation
Abstract The Receptor for Advanced Glycation Endproducts [RAGE] is an evolutionarily
recent member of the immunoglobulin super-family, encoded in the Class III region of the …
recent member of the immunoglobulin super-family, encoded in the Class III region of the …
High-mobility group box 1 and cancer
High-mobility group box 1 protein (HMGB1), a chromatin associated nuclear protein and
extracellular damage associated molecular pattern molecule (DAMP), is an evolutionarily …
extracellular damage associated molecular pattern molecule (DAMP), is an evolutionarily …
High mobility group box 1 release from hepatocytes during ischemia and reperfusion injury is mediated by decreased histone deacetylase activity
J Evankovich, SW Cho, R Zhang, J Cardinal… - Journal of Biological …, 2010 - ASBMB
The mobilization and extracellular release of nuclear high mobility group box-1 (HMGB1) by
ischemic cells activates inflammatory pathways following liver ischemia/reperfusion (I/R) …
ischemic cells activates inflammatory pathways following liver ischemia/reperfusion (I/R) …
HMGB1 enhances the proinflammatory activity of lipopolysaccharide by promoting the phosphorylation of MAPK p38 through receptor for advanced glycation end …
YH Qin, SM Dai, GS Tang, J Zhang, D Ren… - The Journal of …, 2009 - journals.aai.org
High mobility group box-1 (HMGB1) protein was originally characterized as a nuclear DNA-
binding protein, and was described to have an extracellular role when involved in cellular …
binding protein, and was described to have an extracellular role when involved in cellular …
Regulation of HMGB1 release by inflammasomes
High mobility group box 1 (HMGB1) is an evolutionarily conserved non-histone chromatin-
binding protein. During infection or injury, activated immune cells and damaged cells …
binding protein. During infection or injury, activated immune cells and damaged cells …
[PDF][PDF] High‐mobility group box‐1 and liver disease
High‐mobility group box‐1 (HMGB1) is a ubiquitous protein. While initially thought to be
simply an architectural protein due to its DNA‐binding ability, evidence from the last decade …
simply an architectural protein due to its DNA‐binding ability, evidence from the last decade …