Inflammasomes play a crucial role in innate immunity by serving as signaling platforms
which deal with a plethora of pathogenic products and cellular products associated with …

Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from
anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag …

Osteoporosis is a systemic bone metabolism disease that often causes complications, such
as fractures, and increases the risk of death. The nucleotide-binding oligomerization domain …

The inflammasome is a three-component (sensor, adaptor, and effector) filamentous
signaling platform that shields from multiple pathogenic infections by stimulating the …

Type 2 diabetes mellitus (T2DM), accounting for 90–95% cases of diabetes, is characterized
by chronic inflammation. The mechanisms that control inflammation activation in T2DM are …

Sepsis-associated encephalopathy (SAE) is a common complication that leads to long-term
cognitive impairments and increased mortality in sepsis survivors. The mechanisms …

Bipolar disorder is a decidedly heterogeneous and multifactorial disease, with a high
individual and societal burden. While not all patients display overt markers of elevated …

Gluconic metabolic reprogramming, immune response, and inflammation are intimately
linked. Glycolysis involves in the pathologic progress in acute and chronic inflammatory …

Nucleotide-binding oligomerization domain-Like Receptor with a Pyrin domain 3 (NLRP3)
inflammasome was emerged as a marker of metabolic dysregulation. We revealed that age …

The exact mechanism of myocardial hypertrophy has not been completely elucidated. NOD-
like receptor protein 3 (NLRP3) and the pyroptotic cascade play a critical role in cardiac …