Natural products, a chemically and structurally diverse class of molecules, possess a wide
spectrum of biological activities, have been used therapeutically for millennia, and have …

The design of drugs from natural products is a re-emerging area due to the need for
bioactive compounds. The exploitation of natural products and their derivatives obtained by …

Cytochrome P450s are heme-thiolate enzymes that have been broadly applied in
pharmaceutical and biosynthesis because of their efficient oxidation at inert carbons …

Dye‐decolorizing peroxidases (DyP) were originally discovered in fungi for their ability to
decolorize several different industrial dyes. DyPs catalyze the oxidation of a variety of …

Many scientific fields, although driven by similar purposes and dealing with similar
technologies, often appear so isolated and far from each other that even the vocabularies to …

CYP102A1 (BM3) is a catalytically self-sufficient flavocytochrome fusion protein isolated
from Bacillus megaterium, which displays similar metabolic capabilities to many drug …

Polymorphism is an important aspect in drug metabolism responsible for different individual
response to drug dosage, often leading to adverse drug reactions. Here human CYP2C9 as …

The cytochrome P450 superfamily are heme-thiolate enzymes able to carry out
monooxygenase reactions. Several studies have demonstrated the feasibility of using a …

Members of class VII cytochromes P450 are catalytically self-sufficient enzymes containing a
phthalate dioxygenase reductase-like domain fused to the P450 catalytic domain. Among …

The functional significance of cytochrome P450s (CYP) enzymes is their ability to catalyze
the biotransformation of xenobiotics and endogenous compounds. P450 enzymes catalyze …