Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) model: A good alternative to study PCa progression and chemoprevention approaches

LA Kido, C de Almeida Lamas, MR Maróstica Jr… - Life sciences, 2019 - Elsevier
The use of genetically modified animals has been studied in scientific research over time as
a way to discover new treatments or even a cure for various diseases. Transgenic …

The role of the metzincin superfamily in prostate cancer progression: A systematic-like review

MJ Binder, AC Ward - International Journal of Molecular Sciences, 2021 - mdpi.com
Prostate cancer remains a leading cause of cancer-related morbidity in men. Potentially
important regulators of prostate cancer progression are members of the metzincin …

Nintedanib antiangiogenic inhibitor effectiveness in delaying adenocarcinoma progression in Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP)

RF da Silva, E Nogueira-Pangrazi, LA Kido… - Journal of biomedical …, 2017 - Springer
Background In recent times, anti-cancer treatments have focused on Fibroblast Growth
Factor (FGF) and Vascular-Endothelial Growth Factor (VEGF) pathway inhibitors so as to …

Anti-inflammatory therapies in TRAMP mice: delay in PCa progression

LA Kido, F Montico, R Sauce… - Endocrine-related …, 2016 - erc.bioscientifica.com
The aim of this study was to characterize the structural and molecular biology as well as
evaluate the immediate and late responses of prostatic cancer in the transgenic …

The mineral dust-induced gene, mdig, regulates angiogenesis and lymphangiogenesis in lung adenocarcinoma by modulating the expression of VEGF-A/C/D via …

H Zhou, F Geng, Y Chen, J Du, X Zhang… - Oncology …, 2021 - spandidos-publications.com
Mineral dust‑induced gene (mdig) is a novel lung cancer‑related oncogene. The aim of this
study was to explore the effects of mdig on angiogenesis and lymphangiogenesis by …

Prostatic angiogenic responses in late life: antiangiogenic therapy influences and relation with the glandular microenvironment in the transgenic adenocarcinoma of …

F Montico, LA Kido, AC Hetzl, VHA Cagnon - The Prostate, 2015 - Wiley Online Library
BACKGROUND Aging is considered one of the main predisposing factors for the
development of prostate malignancies. Angiogenesis is fundamental for tumor growth and …

Reactive stroma in the prostate during late life: the role of microvasculature and antiangiogenic therapy influences

F Montico, LA Kido, R San Martin, DR Rowley… - The …, 2015 - Wiley Online Library
BACKGROUND Prostate cancer is associated to a reactive stroma microenvironment
characterized by angiogenic processes that are favorable for tumor progression …

Jaboticaba Peel Extract Exerts Chemopreventive Effects in Transgenic Mouse Model of Prostate Cancer

E Nogueira-Lima, C de Almeida Lamas… - The Natural Products …, 2024 - benthamdirect.com
Introduction: Angiogenesis, oxidative stress, and epigenetic alterations involved in prostate
cancer (PCa) are associated with different risk factors, such as a high-fat diet (HFD) …

[HTML][HTML] Brazilian Berry Extract Chemopreventive Action: Hormone Receptors as a Target to Mitigate Aging Prostatic Disorders.

MB Longo, CA Lamas, IU Rossetto… - Brazilian Archives of …, 2022 - SciELO Brasil
SciELO - Brasil - Brazilian Berry Extract Chemopreventive Action: Hormone Receptors as a
Target to Mitigate Aging Prostatic Disorders. Brazilian Berry Extract Chemopreventive Action …

Antiangiogenic therapy with Nintedanib affects hypoxia, angiogenesis and apoptosis in the ventral prostate of TRAMP animals

RF da Silva, TP Banzato, LF Alves, JE Carvalho… - Cell and tissue …, 2020 - Springer
The antiangiogenic therapy for prostate cancer with Nintedanib, a potent inhibitor of
important growth factor receptors, has been proven to delay tumor progression and arrest …