Nano drug delivery systems for antisense oligonucleotides (ASO) therapeutics
Cancer, infectious diseases, and metabolic and hereditary genetic disorders are a global
health burden affecting millions of people, with contemporary treatments offering limited …
health burden affecting millions of people, with contemporary treatments offering limited …
Reconsidering plant memory: Intersections between stress recovery, RNA turnover, and epigenetics
Plants grow in dynamic environments where they can be exposed to a multitude of stressful
factors, all of which affect their development, yield, and, ultimately, reproductive success …
factors, all of which affect their development, yield, and, ultimately, reproductive success …
Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis
Abstract N 6-methyladenosine (m 6 A) is the most common internal modification in
eukaryotic mRNA. It is dynamically installed and removed, and acts as a new layer of mRNA …
eukaryotic mRNA. It is dynamically installed and removed, and acts as a new layer of mRNA …
The challenges and strategies of antisense oligonucleotide drug delivery
M Gagliardi, AT Ashizawa - Biomedicines, 2021 - mdpi.com
Antisense oligonucleotides (ASOs) are used to selectively inhibit the translation of disease-
associated genes via Ribonuclease H (RNaseH)-mediated cleavage or steric hindrance …
associated genes via Ribonuclease H (RNaseH)-mediated cleavage or steric hindrance …
Nanomedicine-based approaches for mRNA delivery
Messenger RNA (mRNA) has immense potential for developing a wide range of therapies,
including immunotherapy and protein replacement. As mRNA presents no risk of integration …
including immunotherapy and protein replacement. As mRNA presents no risk of integration …
[HTML][HTML] HDLBP-stabilized lncFAL inhibits ferroptosis vulnerability by diminishing Trim69-dependent FSP1 degradation in hepatocellular carcinoma
J Yuan, T Lv, J Yang, Z Wu, L Yan, J Yang, Y Shi - Redox Biology, 2022 - Elsevier
Recent studies have suggested that exploring the potential mechanisms regulating
ferroptosis vulnerability may contribute to improving the systemic therapeutic efficacy in …
ferroptosis vulnerability may contribute to improving the systemic therapeutic efficacy in …
Multiplexed and programmable regulation of gene networks with an integrated RNA and CRISPR/Cas toolkit in human cells
RNA-based regulation and CRISPR/Cas transcription factors (CRISPR-TFs) have the
potential to be integrated for the tunable modulation of gene networks. A major limitation of …
potential to be integrated for the tunable modulation of gene networks. A major limitation of …
[HTML][HTML] RNase H1-dependent antisense oligonucleotides are robustly active in directing RNA cleavage in both the cytoplasm and the nucleus
XH Liang, H Sun, JG Nichols, ST Crooke - Molecular therapy, 2017 - cell.com
RNase H1-dependent antisense oligonucleotides (ASOs) are active in reducing levels of
both cytoplasmic mRNAs and nuclear retained RNAs. Although ASO activity in the nucleus …
both cytoplasmic mRNAs and nuclear retained RNAs. Although ASO activity in the nucleus …
Coronavirus Nsp1: immune response suppression and protein expression inhibition
Coronaviruses have brought severe challenges to public health all over the world in the past
20years. SARS-CoV-2, the causative agent of the COVID-19 pandemic that has led to …
20years. SARS-CoV-2, the causative agent of the COVID-19 pandemic that has led to …
Bacterial ribonucleases and their roles in RNA metabolism
DH Bechhofer, MP Deutscher - Critical reviews in biochemistry and …, 2019 - Taylor & Francis
Ribonucleases (RNases) are mediators in most reactions of RNA metabolism. In recent
years, there has been a surge of new information about RNases and the roles they play in …
years, there has been a surge of new information about RNases and the roles they play in …