Precision medicine advances in idiopathic pulmonary fibrosis

T Karampitsakos, BM Juan-Guardela, A Tzouvelekis… - …, 2023 - thelancet.com
Idiopathic pulmonary fibrosis (IPF) is a highly heterogeneous, unpredictable and ultimately
lethal chronic lung disease. Over the last decade, two anti-fibrotic agents have been shown …

What's in a name? That which we call IPF, by any other name would act the same

AU Wells, KK Brown, KR Flaherty… - European …, 2018 - publications.ersnet.org
Idiopathic pulmonary fibrosis (IPF) remains a truly idiopathic fibrotic disease, with a modest
genetic predilection and candidate triggers but no overall explanation for the development of …

Emerging delivery approaches for targeted pulmonary fibrosis treatment

R Diwan, HN Bhatt, E Beaven, M Nurunnabi - Advanced drug delivery …, 2024 - Elsevier
Pulmonary fibrosis (PF) is a progressive, and life-threatening interstitial lung disease which
causes scarring in the lung parenchyma and thereby affects architecture and functioning of …

Novel drug delivery systems and disease models for pulmonary fibrosis

R Li, Y Jia, X Kong, Y Nie, Y Deng, Y Liu - Journal of Controlled Release, 2022 - Elsevier
Pulmonary fibrosis (PF) is a serious and progressive lung disease which is possibly life-
threatening. It causes lung scarring and affects lung functions including epithelial cell injury …

Citrullinated vimentin mediates development and progression of lung fibrosis

FJ Li, R Surolia, H Li, Z Wang, G Liu… - Science translational …, 2021 - science.org
The mechanisms by which environmental exposures contribute to the pathogenesis of lung
fibrosis are unclear. Here, we demonstrate an increase in cadmium (Cd) and carbon black …

Engineered cell and tissue models of pulmonary fibrosis

A Sundarakrishnan, Y Chen, LD Black… - Advanced drug delivery …, 2018 - Elsevier
Pulmonary fibrosis includes several lung disorders characterized by scar formation and
Idiopathic Pulmonary Fibrosis (IPF) is a particularly severe form of pulmonary fibrosis of …

[HTML][HTML] Mitochondrial quality control in pulmonary fibrosis

JL Larson-Casey, C He, AB Carter - Redox Biology, 2020 - Elsevier
Mechanisms underlying the pathogenesis of pulmonary fibrosis remain incompletely
understood. Emerging evidence suggests changes in mitochondrial quality control are a …

Fibronectin on the surface of extracellular vesicles mediates fibroblast invasion

D Chanda, E Otoupalova, KP Hough… - American journal of …, 2019 - atsjournals.org
Extracellular vesicles (EVs) are endosome and plasma membrane–derived nano-sized
vesicles that participate in intercellular signaling. Although EV cargo may signal via multiple …

Progress in understanding and treating idiopathic pulmonary fibrosis: Recent insights and emerging therapies

H Guo, J Sun, S Zhang, Y Nie, S Zhou… - Frontiers in …, 2023 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a long-lasting, continuously advancing, and irrevocable
interstitial lung disorder with an obscure origin and inadequately comprehended …

Targeting GPCR signaling for idiopathic pulmonary fibrosis therapies

AJ Haak, MT Ducharme, AMD Espinosa… - Trends in …, 2020 - cell.com
A variety of G protein-coupled receptors (GPCRs) have been implicated in the pathogenesis
of pulmonary fibrosis, largely through their promotion of profibrotic fibroblast activation. By …