Drug metabolism and pharmacokinetics (DMPK) is an important branch of pharmaceutical
sciences. The nature of ADME (absorption, distribution, metabolism, excretion) and PK …

The effect of membrane transporters on drug disposition, efficacy and safety is now well
recognized. Since the initial publication from the International Transporter Consortium …

A comprehensive characterization of regulatory elements in the chicken genome across
tissues will have substantial impacts on both fundamental and applied research. Here, we …

Drug-drug interactions (DDIs) arising from the perturbation of drug metabolising enzyme
activities represent both a clinical problem and a potential economic loss for the …

Mathematical models, such as physiologically‐based pharmacokinetic models, are used to
predict, for example, drug disposition and toxicity. However, populations differ in the …

Enzymes of the UDP-glucuronosyltransferase (UGT) superfamily contribute to the
elimination of drugs from almost all therapeutic classes. Awareness of the importance of …

Protein abundance data of drug-metabolizing enzymes and transporters (DMETs) are useful
for scaling in vitro and animal data to humans for accurate prediction and interpretation of …

Organic solute transporter alpha/beta (OSTα/β) is a heteromeric solute carrier protein that
transports bile acids, steroid metabolites and drugs into and out of cells. OSTα/β protein is …

Most drugs are administered to children orally. An information gap remains on the protein
abundance of small intestinal drug-metabolizing enzymes (DMEs) and drug transporters …

The purpose of this review is to summarize the current knowledge on three physiological
determinants of oral drug absorption, ie, gastric emptying, volumes and composition of …