Understanding the detailed mechanism behind every human disease, disorder, defect, and
deficiency is a daunting task concerning the clinical diagnostic tools for patients. Hence, a …

Since their isolation in the early 1990s, members of the Hedgehog family of intercellular
signaling proteins have come to be recognized as key mediators of many fundamental …

Zebrafish (Danio rerio) has been a prominent model vertebrate in a variety of biological
disciplines. Substantial information gathered from developmental and genetic research …

In a large-scale screen, we isolated mutants displaying a specific visible phenotype in
embryos or early larvae of the zebrafish, Danio rerio. Males were mutagenized with …

The zebrafish has become one of the most important model organisms to study biologial
processes in vivo. As a vertebrate that has many of the strengths of invertebrate model …

Traditionally, cartilage is stained by alcian blue using acidic conditions to differentiate tissue
staining. The acidic conditions are problematic when one wishes to stain the same …

The appearance of molecular differences between arterial and venous endothelial cells
before circulation suggests that genetic factors determine these cell types. We find that …

Lateral inhibition, mediated by Notch signaling, leads to the selection of cells that are
permitted to become neurons within domains defined by proneural gene expression …

Zebrafish embryos and larvae have stage-specific patterns of motility or locomotion. Two
embryonic structures accomplish this behavior: the central nervous system (CNS) and …

▪ Abstract Embryological and genetic studies of mouse, bird, zebrafish, and frog embryos are
providing new insights into the regulatory functions of the myogenic regulatory factors …