Background New concepts in resuscitation from hemorrhagic shock (or renewed interest in
older concepts) have been emerging in recent years. A report from 1993 noted that initial …

Hemorrhage is a top cause of death after injury and is the leading cause of potentially
preventable trauma deaths. 1–3 In contrast to other causes of trauma death, such as …

We have recently demonstrated that injured patients in hemorrhagic shock shed syndecan 1
and that the early use of fresh frozen plasma (FFP) in these patients is correlated with …

Animal models are essential to gain a deeper understanding of the pathophysiology
associated with traumatic brain injury (TBI). Rodent models of TBI have proven highly …

Acute central nervous system injury, encompassing traumatic brain injury (TBI) and stroke,
accounts for a significant burden of morbidity and mortality worldwide. Studies in animal …

Over the past century, blood banking and transfusion practices have moved from whole
blood therapy to components. In trauma patients, the shift to component therapy was …

Non-compressible torso hemorrhage (NCTH) is associated with significant mortality in
preventable deaths, both in the field and in civilian settings. Current management strategies …

BACKGROUND We hypothesize that limited transthoracic echocardiogram (LTTE) is a
useful tool to guide therapy during the initial phase of resuscitation in trauma patients …

BACKGROUND Nonoperative multidisciplinary management for severe (American
Association for the Surgery of Trauma Grades IV and V) liver injury has been used for two …

BACKGROUND Traumatic brain injury (TBI) and hemorrhagic shock (HS) can be associated
with coagulopathy and inflammation, but the mechanisms are poorly understood. We …