In vivo, the interior and exterior of cells is populated by various macromolecules that create
an extremely crowded milieu. Yet again, in vitro eukaryotic cell culture is conducted in dilute …

The development of therapeutic regenerative medicine and accurate drug discovery cell-
based products requires effective, with respect to obtaining sufficient numbers of viable …

Macromolecular crowding bridges in vivo and in vitro studies by simulating cellular
complexities such as high viscosity and limited space while maintaining the experimental …

The cellular environment is crowded by macromolecules of various sizes, shapes, and
charges, which modulate protein structure, function and dynamics. Herein, we contemplated …

One of the main differences in the intercellular environment compared to the laboratory
condition is the presence of macromolecular crowders of various compositions, sizes, and …

Over the past 20 years, the most studied and debated aspect of macromolecular crowding is
how it affects protein stability. Traditionally, it is explained by a delicate balance between the …

The two-week protein biochemistry experience described herein focuses on reinforcing key
biochemical concepts and achieving significant learning domain accomplishments for …

By using classical density functional theory, we study the effects of interionic nonhard sphere
neutral interaction (NHSNI) and solvent crowding on curve of differential electrical …

The intricate interplay of macromolecules within biological systems significantly influences
the behavior of therapeutic agents, making the understanding of macromolecular crowding …

Macromolecular crowding can change kinetics of enzyme catalysis. How interaction
between enzymes and neighboring macromolecules contributes to the crowding effect on …