Schizophrenia is frequently characterized as a disorder of brain connectivity. Neuroimaging
has played a central role in supporting this view, with nearly two decades of research …

The disconnection hypothesis suggests that the core symptoms of schizophrenia (SZ) are
related to aberrant, or 'dys-', connectivity between distinct brain regions. A proliferation of …

Context A substantial proportion of people at clinical high risk of psychosis will develop a
psychotic disorder over time. However, the risk of transition to psychosis varies between …

Dysfunction of the mesocorticolimbic dopaminergic reward system is a core feature of
schizophrenia (SZ), yet its precise contributions to different stages of reward processing and …

Published reports of functional abnormalities in schizophrenia remain divergent due to lack
of staging point-of-view and whole-brain analysis. To identify key functional-connectivity …

BACKGROUND: Individual structural imaging studies in the pre-psychotic phases deliver
contrasting findings and are unable to definitively characterize the neuroanatomical …

Schizophrenia is a chronic psychiatric disorder with a heterogeneous genetic and
neurobiological background that influences early brain development, and is expressed as a …

Background: Despite impressive advancements in early interventions in psychosis, there is
an urgent need of robust neurobiological markers to improve the predictive value of …

Functional and structural brain imaging has identified neural and neurotransmitter systems
involved in schizophrenia and their link to cognitive and behavioural disturbances such as …

Since its inception in 1992, Functional Magnetic Resonance Imaging (fMRI) has become an
indispensible tool for studying cognition in both the healthy and dysfunctional brain. FMRI …