Apathy, executive function, and emotion recognition are the main drivers of functional impairment in behavioral variant of frontotemporal dementia

G Musa Salech, P Lillo, K Van der Hiele… - Frontiers in …, 2022 - frontiersin.org
Background: The cognitive and neuropsychiatric deficits present in patients with behavioral
variant frontotemporal dementia (bvFTD) are associated with loss of functionality in the …

A Multidimensional, Person-Centered Framework for Functional Assessment in Dementia: Insights from the 'What','How','To Whom', and 'How Much'Questions

A Slachevsky, F Grandi, D Thumala… - Journal of …, 2024 - content.iospress.com
Dementia is a syndrome characterized by cognitive and neuropsychiatric symptoms
associated with progressive functional decline (FD). FD is a core diagnostic criterion for …

Mild cognitive impairment history and current procedures in low-and middle-income countries: a brief review

L Hartle, H Charchat-Fichman - Dementia & Neuropsychologia, 2021 - SciELO Brasil
Mild cognitive impairment (MCI) is a widely studied concept that has changed over time.
Epidemiology, diagnosis, costs, prognostics, screening procedures, and categorization have …

[HTML][HTML] The striatum, the hippocampus, and short-term memory binding: Volumetric analysis of the subcortical grey matter's role in mild cognitive impairment

MCV Hernández, R Clark, SH Wang, F Guazzo… - NeuroImage: Clinical, 2020 - Elsevier
Background Deficits in short-term memory (STM) binding are a distinguishing feature of
preclinical stages leading to Alzheimer's disease (AD). However, the neuroanatomical …

Barriers to effective memory assessments for Alzheimer's disease

MA Parra - Journal of Alzheimer's Disease, 2022 - content.iospress.com
Abstract Recently, Alzheimer's Disease International (ADI) stressed that around 75% of
people living with dementia globally are still not receiving a diagnosis. In this commentary, I …

Safety, tolerability, and efficacy estimate of evoked gamma oscillation in mild to moderate Alzheimer's disease

M Hajós, A Boasso, E Hempel, M Shpokayte… - Frontiers in …, 2024 - frontiersin.org
Background Alzheimer's Disease (AD) is a multifactorial, progressive neurodegenerative
disease that disrupts synaptic and neuronal activity and network oscillations. It is …

Insula and amygdala atrophy are associated with functional impairment in subjects with presbycusis

C Belkhiria, RC Vergara, S San Martin… - Frontiers in aging …, 2020 - frontiersin.org
Hearing loss is an important risk factor for dementia. However, the mechanisms that relate
these disorders are still unknown. As a proxy of this relationship, we studied the structural …

Predictors of functional impairment and awareness in people with dementia, mild cognitive impairment and healthy older adults from a middle-income country

L Hartle, DC Mograbi, HC Fichman, CA Faria… - Frontiers in …, 2022 - frontiersin.org
Objective To investigate the demographic, clinical and cognitive correlates of functional
capacity and its awareness in people with dementia (PwD; n= 104), mild cognitive …

The “when” matters: Evidence from memory markers in the clinical continuum of Alzheimer's disease.

G Forno, MA Parra, D Thumala, R Villagra… - …, 2023 - psycnet.apa.org
Objective: Cognitive assessment able to detect impairments in the early neuropathological
stages of Alzheimer's disease (AD) is urgently needed. The visual short-term memory …

Design, synthesis, biological evaluation, and molecular modeling simulations of new phthalazine‐1, 4‐dione derivatives as anti‐Alzheimer's agents

D Nuha, AE Evren, BNS Özkan… - Archiv der …, 2024 - Wiley Online Library
The development of targeted phthalazine‐1, 4‐dione acetylcholinesterase (AChE) inhibitors
for treating Alzheimer's disease involved the synthesis of 32 compounds via a multistage …