Cell–extracellular matrix mechanotransduction in 3D

A Saraswathibhatla, D Indana… - Nature Reviews Molecular …, 2023 - nature.com
Mechanical properties of extracellular matrices (ECMs) regulate essential cell behaviours,
including differentiation, migration and proliferation, through mechanotransduction. Studies …

Glycosaminoglycans: what remains to be deciphered?

S Perez, O Makshakova, J Angulo, E Bedini, A Bisio… - Jacs Au, 2023 - ACS Publications
Glycosaminoglycans (GAGs) are complex polysaccharides exhibiting a vast structural
diversity and fulfilling various functions mediated by thousands of interactions in the …

From mechanical resilience to active material properties in biopolymer networks

F Burla, Y Mulla, BE Vos, A Aufderhorst-Roberts… - Nature Reviews …, 2019 - nature.com
The cells and tissues that make up our body manage contradictory mechanical demands. It
is crucial for their survival to be able to withstand large mechanical loads, but it is equally …

Glycosaminoglycans modulate long-range mechanical communication between cells in collagen networks

X Chen, D Chen, E Ban, KC Toussaint… - Proceedings of the …, 2022 - National Acad Sciences
Cells can sense and respond to mechanical forces in fibrous extracellular matrices (ECMs)
over distances much greater than their size. This phenomenon, termed long-range force …

Composite Hydrogels in Three-Dimensional in vitro Models

Z Zhao, C Vizetto-Duarte, ZK Moay… - … in Bioengineering and …, 2020 - frontiersin.org
3-dimensional (3D) in vitro models were developed in order to mimic the complexity of real
organ/tissue in a dish. They offer new possibilities to model biological processes in more …

Motility-induced fracture reveals a ductile-to-brittle crossover in a simple animal's epithelia

VN Prakash, MS Bull, M Prakash - Nature Physics, 2021 - nature.com
Epithelial tissues provide an important barrier function in animals, but these tissues are
subjected to extreme strains during day-to-day activities such as feeding and locomotion …

Engineered biomaterial platforms to study fibrosis

MD Davidson, JA Burdick… - Advanced healthcare …, 2020 - Wiley Online Library
Many pathologic conditions lead to the development of tissue scarring and fibrosis, which
are characterized by the accumulation of abnormal extracellular matrix (ECM) and changes …

Progress in the mechanical modulation of cell functions in tissue engineering

K Dey, E Roca, G Ramorino, L Sartore - Biomaterials Science, 2020 - pubs.rsc.org
In mammals, mechanics at multiple stages—nucleus to cell to ECM—underlie multiple
physiological and pathological functions from its development to reproduction to death …

Pengaruh manajemen stress dan kelola emosi terhadap tingkat kecemasan siswa di masa new normal

P Sari, SZ Bulantika, FP Utami… - Bulletin of Counseling …, 2020 - journal.kurasinstitute.com
The purpose of this study was to see the effect of stress management and emotional
management on students' anxiety levels in the new normal. This research is an ex post facto …

Biomimetic approaches for the design and fabrication of bone-to-soft tissue interfaces

C Pitta Kruize, S Panahkhahi, NE Putra… - ACS Biomaterials …, 2021 - ACS Publications
Bone-to-soft tissue interfaces are responsible for transferring loads between tissues with
significantly dissimilar material properties. The examples of connective soft tissues are …