RNA modifications in physiology and disease: towards clinical applications
The ability of chemical modifications of single nucleotides to alter the electrostatic charge,
hydrophobic surface and base pairing of RNA molecules is exploited for the clinical use of …
hydrophobic surface and base pairing of RNA molecules is exploited for the clinical use of …
The proteins of mRNA modification: writers, readers, and erasers
MN Flamand, M Tegowski… - Annual review of …, 2023 - annualreviews.org
Over the past decade, mRNA modifications have emerged as important regulators of gene
expression control in cells. Fueled in large part by the development of tools for detecting …
expression control in cells. Fueled in large part by the development of tools for detecting …
Exon-intron boundary inhibits m6A deposition, enabling m6A distribution hallmark, longer mRNA half-life and flexible protein coding
Z Luo, Q Ma, S Sun, N Li, H Wang, Z Ying… - Nature …, 2023 - nature.com
Regional bias of N 6-methyladenosine (m6A) mRNA modification avoiding splice site
region, calls for an open hypothesis whether exon-intron boundary could affect m6A …
region, calls for an open hypothesis whether exon-intron boundary could affect m6A …
Single-molecule epitranscriptomic analysis of full-length HIV-1 RNAs reveals functional roles of site-specific m6As
A Baek, GE Lee, S Golconda, A Rayhan… - Nature …, 2024 - nature.com
Although the significance of chemical modifications on RNA is acknowledged, the
evolutionary benefits and specific roles in human immunodeficiency virus (HIV-1) replication …
evolutionary benefits and specific roles in human immunodeficiency virus (HIV-1) replication …
IGF2BP3 promotes mRNA degradation through internal m7G modification
Recent studies have suggested that mRNA internal m7G and its writer protein METTL1 are
closely related to cell metabolism and cancer regulation. Here, we identify that IGF2BP …
closely related to cell metabolism and cancer regulation. Here, we identify that IGF2BP …
Base-resolution m5C profiling across the mammalian transcriptome by bisulfite-free enzyme-assisted chemical labeling approach
L Lu, X Zhang, Y Zhou, Z Shi, X Xie, X Zhang, L Gao… - Molecular Cell, 2024 - cell.com
methylcytosine (m 5 C) is a prevalent RNA modification crucial for gene expression
regulation. However, accurate and sensitive m 5 C sites identification remains challenging …
regulation. However, accurate and sensitive m 5 C sites identification remains challenging …
[HTML][HTML] A lncRNA from the FTO locus acts as a suppressor of the m6A writer complex and p53 tumor suppression signaling
Summary N 6-methyladenosine (m 6 A) of mRNAs modulated by the METTL3-METTL14-
WTAP-RBM15 methyltransferase complex and m 6 A demethylases such as FTO play …
WTAP-RBM15 methyltransferase complex and m 6 A demethylases such as FTO play …
Single-cell m6A profiling in the mouse brain uncovers cell type-specific RNA methylomes and age-dependent differential methylation
Abstract N 6-methyladenosine (m6A) is an abundant mRNA modification in the brain that
has important roles in neurodevelopment and brain function. However, because of technical …
has important roles in neurodevelopment and brain function. However, because of technical …
Advances in targeting RNA modifications for anticancer therapy
MM Pomaville, C He - Trends in Cancer, 2023 - cell.com
Numerous strategies are employed by cancer cells to control gene expression and facilitate
tumorigenesis. In the study of epitranscriptomics, a diverse set of modifications to RNA …
tumorigenesis. In the study of epitranscriptomics, a diverse set of modifications to RNA …