In breast conserving surgery, the tumor should be removed with a clean margin, a rim of
healthy tissue surrounding. Failure to achieve clean margins in the initial surgery results in a …

Light scattering has become a common biomedical research tool, enabling diagnostic
sensitivity to myriad tissue alterations associated with disease. Light–tissue interactions are …

Purpose: Complete tumor removal during cancer surgery remains challenging due to the
lack of accurate techniques for intraoperative margin assessment. This study evaluates the …

Abstract Introduction Nationally, 25% to 50% of patients undergoing lumpectomy for local
management of breast cancer require a secondary excision because of the persistence of …

Localized measurements of scattering in biological tissue provide sensitivity to
microstructural morphology but have limited utility to wide-field applications, such as surgical …

Open-top light-sheet microscopy is a technique that can potentially enable rapid ex vivo
inspection of large tissue surfaces and volumes. Here, we have optimized an open-top light …

This study investigates the hypothesis that structured light reflectance imaging with high
spatial frequency patterns (f_x) can be used to quantitatively map the anisotropic scattering …

Determination of chemotherapy efficacy early during treatment would provide more
opportunities for physicians to alter and adapt treatment plans. Diffuse optical technologies …

Breast cancer is a complex disease characterized by many morphological, clinical, and
molecular features. For many years, breast cancer has been classified according to …

The feasibility of spatial frequency domain imaging (SFDI) for breast surgical margin
assessment was evaluated in tissue-simulating phantoms and in fully intact lumpectomy …