Glucose transporters as a target for anticancer therapy
M Pliszka, L Szablewski - Cancers, 2021 - mdpi.com
Simple Summary For mammalian cells, glucose is a major source of energy. In the presence
of oxygen, a complete breakdown of glucose generates 36 molecules of ATP from one …
of oxygen, a complete breakdown of glucose generates 36 molecules of ATP from one …
Molecular and cellular mechanisms of propolis and its polyphenolic compounds against cancer
N Oršolić, M Jazvinšćak Jembrek - International journal of molecular …, 2022 - mdpi.com
In recent years, interest in natural products such as alternative sources of pharmaceuticals
for numerous chronic diseases, including tumors, has been renewed. Propolis, a natural …
for numerous chronic diseases, including tumors, has been renewed. Propolis, a natural …
Microbiome—microbial metabolome—cancer cell interactions in breast cancer—familiar, but unexplored
Breast cancer is a leading cause of death among women worldwide. Dysbiosis, an aberrant
composition of the microbiome, characterizes breast cancer. In this review we discuss the …
composition of the microbiome, characterizes breast cancer. In this review we discuss the …
Flavonoids against the Warburg phenotype—Concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism
The Warburg effect is characterised by increased glucose uptake and lactate secretion in
cancer cells resulting from metabolic transformation in tumour tissue. The corresponding …
cancer cells resulting from metabolic transformation in tumour tissue. The corresponding …
Anti-cancer effects of polyphenols via targeting p53 signaling pathway: Updates and future directions
The anticancer effects of polyphenols are ascribed to several signaling pathways including
the tumor suppressor gene tumor protein 53 (p53). Expression of endogenous p53 is silent …
the tumor suppressor gene tumor protein 53 (p53). Expression of endogenous p53 is silent …
Targeting glucose transporters for breast cancer therapy: the effect of natural and synthetic compounds
AM Barbosa, F Martel - Cancers, 2020 - mdpi.com
Reprogramming of cellular energy metabolism is widely accepted to be a cancer hallmark.
The deviant energetic metabolism of cancer cells-known as the Warburg effect-consists in …
The deviant energetic metabolism of cancer cells-known as the Warburg effect-consists in …
An overview on genistein and its various formulations
Genistein is the natural isoflavone and a phytoestrogen with a broad range of
pharmacological properties, such as tyrosine and topoisomerase inhibition. It also induces …
pharmacological properties, such as tyrosine and topoisomerase inhibition. It also induces …
Saccharomyces cerevisiae exponential growth kinetics in batch culture to analyze respiratory and fermentative metabolism
IK Olivares-Marin… - Journal of …, 2018 - pmc.ncbi.nlm.nih.gov
Saccharomyces cerevisiae cells in the exponential phase sustain their growth by producing
ATP through fermentation and/or mitochondrial respiration. The fermentable carbon …
ATP through fermentation and/or mitochondrial respiration. The fermentable carbon …
An appraisal of the current status of inhibition of glucose transporters as an emerging antineoplastic approach: Promising potential of new pan-GLUT inhibitors
Neoplastic cells displayed altered metabolism with accelerated glycolysis. Therefore, these
cells need a mammoth supply of glucose for which they display an upregulated expression …
cells need a mammoth supply of glucose for which they display an upregulated expression …
The dual-role of methylglyoxal in tumor progression–novel therapeutic approaches
A Leone, C Nigro, A Nicolò, I Prevenzano… - Frontiers in …, 2021 - frontiersin.org
One of the hallmarks of cancer cells is their metabolic reprogramming, which includes the
preference for the use of anaerobic glycolysis to produce energy, even in presence of …
preference for the use of anaerobic glycolysis to produce energy, even in presence of …