A Genetically Encoded Photocaged Cysteine for Facile Site-Specific Introduction of Conjugation-Ready Thiol Residues in Antibodies

AO Osgood, SJS Roy, D Koo, R Gu… - Bioconjugate …, 2024 - ACS Publications
Antibody–drug conjugates (ADCs) have emerged as a powerful class of anticancer
therapeutics that enable the selective delivery of toxic payloads into target cells. There is …

Biosynthesis of halogenated tryptophans for protein engineering using genetic code expansion

Y Guo, L Cheng, Y Hu, M Zhang, R Liu, Y Wang… - …, 2024 - Wiley Online Library
Abstract Genetic Code Expansion technology offers significant potential in incorporating
noncanonical amino acids into proteins at precise locations, allowing for the modulation of …

Electrochemical diversification of cysteine derivatives and cysteine-containing peptides to phosphorothioates and sulfinates

L Xiao, Y Li, J Huang, L Pan, P Wu… - Organic Chemistry …, 2024 - pubs.rsc.org
This study explores the application of modified cysteine in oligopeptides to overcome
challenges in amino acid residue modification, with a focus on cysteine. Novel strategies for …

Electrochemistry-empowered nano-labeling for versatile aptamer-based biosensing of tumor-associated proteins

Y Cao, X Yu, Y Cao, Z Huang, J Xu, J Zhao… - Chemical Engineering …, 2025 - Elsevier
Aptamer-based biosensing methods, despite achieving advancements in the detection of
tumor-associated proteins, are only effective for a limited number of specific proteins and …

Electrochemical Bioconjugation of Tryptophan Residues: A Strategy for Peptide Modification

C Wan, R Sun, W Xia, H Jiang, BX Chen, PC Kuo… - Organic …, 2024 - ACS Publications
Interest in electrocatalytic bioconjugation reactions has surged, particularly for modifying
tryptophan and tyrosine residues in proteins. We used a cost-effective graphite felt electrode …