Transposable elements (TEs) or “jumping genes” historically have been disparaged as a
class of “junk DNA” in mammalian genomes (1, 2). The advent of whole genome DNA …

Transposable elements (TEs) are genetic elements capable of changing position within the
genome. Although their mobilization can constitute a threat to genome integrity, nearly half …

By Southern blotting and hybridization analysis using 32P-labeled poly (dT-dG). poly (dC-
dA) as a probe, we have found, in eukaryotic genomes, a huge number of stretches of dT-dG …

Abstract 7SL RNA is an abundant cytoplasmic RNA which functions in protein secretion as a
component of the signal recognition particle1. Alu sequences are the most abundant family …

We present the complete sequence of a cDNA encoding the human amiloride-sensitive
Na+/H+ antiporter. After functional complementation of a mouse fibroblast mutant by gene …

Plasmid vectors have been widely used for DNA vaccines and gene therapy. Following
intramuscular injection, the plasmid that persists is extrachromosomal and integration into …

We report the construction of a genetic linkage map of the mouse, consisting entirely of
genetic markers that can be rapidly typed by polymerase chain reaction and that show a …

Publisher Summary This chapter discusses the structure and organization of mammalian,
highly repeated sequences at the molecular level. There is a description of tandemly …

In situ hybridization (ISH) for the detection of single-or low-copy sequences, particularly
large DNA fragments cloned into YAC or BAC vectors, generally requires the suppression …

Short retroposons (SINEs) are repetitive elements amplified in the genome via an RNA
intermediate, using the enzymatic machinery of autonomous retroposons (LINEs). SINEs are …