Background The transport of transepithelial Cl-and HCO3-is crucial for the function of the
intestinal epithelium and maintains the acid-based homeostasis. Slc26a3 (DRA), as a key …

ABSTRACT SLC26 family members are multifunctional transporters of small anions,
including Cl−, HCO3−, sulfate, oxalate, and formate. Most SLC26 isoforms act as secondary …

Colorectal cancer (CRC) is a formidable disease due to the intricate mechanisms that drive
its proliferation and metastasis. Despite significant progress in cancer research, the …

Background. Multiple genes have been associated with IBD, and many of these can be
linked to alterations in autophagy, UPR, ubiquitination, and metabolic and immune response …

Background & Aims Down-regulation of chloride transporter SLC26A3 or down-regulated in
adenoma (DRA) in colonocytes has recently been linked to the pathogenesis of ulcerative …

SLC26A3 encodes a Cl−/HCO3− ion transporter that is also known as downregulated in
adenoma (DRA) and is involved in HCO3−/mucus formation. The role of DRA in the …

The roundworm Toxocara canis causes toxocariasis in dogs and larval migrans in humans.
Better understanding of the lung response to T. canis infection could explain why T. canis …

Crohn's disease (CD) is a complex chronic inflammatory disorder that may affect any part of
gastrointestinal tract with extra-intestinal manifestations and associated immune …

In polarized intestinal epithelial cells, downregulated in adenoma (DRA) is an apical
Cl−/HCO 3− exchanger that is part of neutral NaCl absorption under baseline conditions, but …

Intestinal disorders are common in metabolic syndrome. However, their pathogenesis is still
not fully understood. Pig and human intestines are highly similar in terms of associated …