The Wnt/β-catenin signaling pathway exerts integral roles in embryogenesis and adult
homeostasis. Aberrant activation of the pathway is implicated in growth-associated diseases …

Besides its important role in embryonic development and homeostatic self-renewal in adult
tissues, Wnt/β-catenin signaling exerts both anti-inflammatory and proinflammatory …

β‐Catenin (Armadillo in Drosophila) is a multitasking and evolutionary conserved molecule
that in metazoans exerts a crucial role in a multitude of developmental and homeostatic …

Nuclear factor (NF)-κB and inhibitor of NF-κB kinase (IKK) proteins regulate many
physiological processes, including the innate-and adaptive-immune responses, cell death …

Tumours progress through a cascade of events that enable the formation of metastases.
Some of the components that are required for this fatal process are well established …

Phosphatidylinositol 3‐kinase (PI3K) and phosphatase and tensin homolog deleted on
chromosome 10 (PTEN) signaling pathway play an important role in multiple cellular …

Metastasis can be viewed as an evolutionary process, culminating in the prevalence of rare
tumour cells that overcame stringent physiological barriers as they separated from their …

The canonical Wnt pathway has gathered much attention in recent years owing to its
fundamental contribution to metazoan development, tissue homeostasis and human …

A decade of intensive investigation of coactivators and corepressors required for regulated
actions of DNA-binding transcription factors has revealed a network of sequentially …

The ability of p53 to induce apoptosis plays an important role in tumor suppression. Here,
we describe a previously unknown posttranslational modification of the DNA-binding …