Although the classic activities of p53 including induction of cell-cycle arrest, senescence,
and apoptosis are well accepted as critical barriers to cancer development, accumulating …

Frequent p53 mutations (mutp53) not only abolish tumor suppressor capacities but confer
various gain-of-function (GOF) activities that impacts molecules and pathways now regarded …

Mitochondrial dynamics are balanced fission and fusion events that regulate mitochondrial
morphology, and alteration in these events results in mitochondrial dysfunction and …

Sestrins (Sesns), highly conserved stress-inducible metabolic proteins, are known to protect
organisms against various noxious stimuli including DNA damage, oxidative stress …

Mitochondria-mediated oxidative stress and apoptosis contribute greatly to early brain injury
(EBI) following subarachnoid hemorrhage (SAH). This study hypothesized that activation of …

The TP53 tumor suppressor gene is the most frequently altered gene in tumors and an
increasing number of studies highlight that mutant p53 proteins can acquire oncogenic …

Abstract p53 is mutated in over half of human cancers. In addition to losing wild-type (WT)
tumor-suppressive function, mutant p53 proteins are proposed to acquire gain-of-function …

Several studies indicate that the cytosolic enzyme glyceraldehyde-3-phosphate
dehydrogenase (GAPDH) has pleiotropic functions independent of its canonical role in …

Over 50% cancer bears TP53 mutation, the highly stabilized mutant p53 protein drives the
tumorigenesis and progression. Mutation of p53 not only cause loss-of-function and …

Despite numerous therapies, cancer remains one of the leading causes of death worldwide
due to the lack of markers for early detection and response to treatment in many patients …