[HTML][HTML] T cell-engaging bispecific antibodies targeting gp100 and PRAME: expanding application from uveal melanoma to cutaneous melanoma

R Reschke, AH Enk, JC Hassel - Pharmaceutics, 2024 - mdpi.com
Uveal melanoma represents a rare and aggressive subtype of melanoma with limited
treatment options and poor prognosis, especially in the metastatic setting. Tebentafusp, a …

Leveraging STING, batf3 dendritic cells, CXCR3 ligands, and other components related to innate immunity to induce A “Hot” Tumor microenvironment that is …

R Reschke, DJ Olson - Cancers, 2022 - mdpi.com
Simple Summary The conceptualization of a “hot” tumor microenvironment has been
characterized by mainly T cell infiltration, whereas,“cold” or “immune-deserted” tumors were …

Prognostic Biomarkers in Evolving Melanoma Immunotherapy

R Reschke, AH Enk, JC Hassel - American journal of clinical dermatology, 2024 - Springer
Melanoma, a highly aggressive form of skin cancer, has seen significant advancements in
treatment through the introduction of immunotherapy. However, the variability in patient …

Chemokines and Cytokines in Immunotherapy of Melanoma and Other Tumors: From Biomarkers to Therapeutic Targets

R Reschke, AH Enk, JC Hassel - International Journal of Molecular …, 2024 - mdpi.com
Chemokines and cytokines represent an emerging field of immunotherapy research. They
are responsible for the crosstalk and chemoattraction of immune cells and tumor cells. For …

Catching Cancer Early: The Importance of Dermato-Oncology Screening

L Stătescu, E Cojocaru, LM Trandafir, E Ţarcă… - Cancers, 2023 - mdpi.com
Simple Summary Skin cancers, either melanocytic (malignant melanoma) or nonmelanocytic
(squamous cell carcinoma, basal cell carcinoma), unlike most types of cancers which are not …

Analytical Validation of an Immunohistochemical 7-Biomarker Prognostic Assay (immunoprint®) for Early-Stage Cutaneous Melanoma in Archival Tissue of Patients …

M Ziemer, B Weidenthaler-Barth, P Gussek, M Pfeiffer… - Diagnostics, 2023 - mdpi.com
Selected patients with early-stage melanoma have a “hidden high risk” of poor oncologic
outcomes. They might benefit from clinical trials, and ultimately, if warranted by trial results …

[HTML][HTML] Late-Onset Masseteric Metastasis of Malignant Melanoma in a Patient With Neurofibromatosis and Lipomatosis: A Diagnostic Challenge and Case Report

MI Borges, JM Abreu, F Ramalhosa, S Nogueira… - Cureus, 2023 - ncbi.nlm.nih.gov
Melanoma and neurofibromatosis (NF) are distinctly separate conditions, each
characterized by unique pathophysiological processes. Nevertheless, their clinical …

[PDF][PDF] Ultra-Late Cutaneous Melanoma Recurrence Following 49 Years of Quiescence

J Sax, C Lamerson - Cutis, 2022 - cdn.mdedge.com
E54 I CUTIS® WWW. MDEDGE. COM/DERMATOLOGY consisting of a 3.7× 1.7-cm skin
ellipse averaging 0.7 cm in thickness. In the center of the specimen was a 0.6-cm, round …

[HTML][HTML] Should patients with PsA or ankylosing spondylitis with axial disease be 'lumped'or 'split'?

L Beresford - blogs.the-hospitalist.org
A new study provides evidence that two conditions that fall under the umbrella of
spondyloarthritis–isolated axial disease in patients with psoriatic arthritis (PsA) and isolated …

[HTML][HTML] Pediatricians urge flu vaccine for children

E Partika - medauth2.mdedge.com
Attention parents: The nation's leading pediatric medical society is urging you to make sure
your children get a flu shot this fall to prevent and control the spread of the illness.The …