Multiple and One-Pot Synthetic Strategies for Pyrimido-Thiazine and their Derivatives

GS Chittilappilly, M Chandran… - Current Organic …, 2022 - benthamdirect.com
In the present era, the use of fused heterocyclic compounds has been showing considerable
value in the development and designing of new drugs. Article flow through the synthetic …

One-pot synthesis of fused isoxazolo [4′, 5′: 4, 5] thiopyrano [2, 3-d] pyrimidines as potent EGFR targeting anti-lung cancer agents

SS Ardhapure, SB Sirsat - Tetrahedron Letters, 2024 - Elsevier
The requirement for scaffolds has prompted synthetic chemists to devise simple and
effective methods for optimal synthesis, which are critical in the medical industry. Under …

Dipyrimido [4, 5-b: 5, 4-e][1, 4] thiazine: synthesis and their enzyme inhibitory activity assessment on soybean 15-lipoxygenase

A Karimian, H Eshghi, M Bakavoli, A Shiri… - Journal of the Iranian …, 2015 - Springer
A series of new derivatives of dipyrimido [4, 5-b: 5, 4-e][1, 4] thiazine were synthesized by
treatment of 5-amino-6-methyl-2-morpholino-4-pyrimidinethiol (1) with 5-bromo-2, 4-dichloro …

Synthesis of Novel Derivatives of (Benz)Imidazo[2,1-b]Pyrimido[4,5-d][1,3]Thiazine

M Akbarzadeh, M Bakavoli… - Journal of Chemical …, 2017 - journals.sagepub.com
Several derivatives of the novel heterocyclic systems 2-substituted-imidazo-and
benzimidazo-[2, 1-b] pyrimido [4, 5-d][1, 3] thiazine have been synthesised through the one …

Synthesis of New Derivatives of 4‐(4,7,7‐Trimethyl‐7,8‐dihydro‐6H‐benzo[b]pyrimido[5,4‐e][1,4]thiazin‐2‐yl)morpholine

A Karimian, H Eshghi, M Bakavoli… - Journal of Heterocyclic …, 2017 - Wiley Online Library
Cyclocondensation of 5‐amino‐6‐methyl‐2‐morpholinopyrimidine‐4‐thiol (1) and 2‐bromo‐
5, 5‐dimethylcyclohexane‐1, 3‐dione (2) under mild reaction condition afforded 4, 7, 7 …

Synthesis of new derivatives of 4-(4-methyl-5H-pyrimido[4,5-b][1,4]thiazin-2-yl)morpholine and 4-methyl-2-(piperidin-1-yl)-5H-pyrimido[4,5-b][1,4]thiazine

A Karimian, H Karimian - Journal of Chemical Research, 2017 - journals.sagepub.com
Several derivatives of the novel 4-(4-methyl-5 H-pyrimido [4, 5-b][1, 4] thiazin-2-yl)
morpholine and 4-methyl-2-(piperidin-1-yl)-5 H-pyrimido [4, 5-b][1, 4] thiazine ring systems …

Synthesis of New Pyrimido[5′,4′:5,6][1,4]thiazino[2,3‐b]quinoxaline Derivatives in One Step

A Karimian - Journal of Heterocyclic Chemistry, 2018 - Wiley Online Library
As a continuation of our search for new heterocyclic compounds, the synthesis of pyrimido
[5′, 4′: 5, 6][1, 4] thiazino [2, 3‐b] quinoxaline ring system is described. A series of new …

Синтез та структурна модифікація S-алкіл-3, 4, 5, 6-тетрагідропіримідин-2-тіону

ТО Прокопчук - 2024 - evnuir.vnu.edu.ua
Робота присвячена розробці ефективного та препаративно зручного методу синтезу 2-
алкілтіо-1, 4, 5, 6-тетрагідропіримідинів та частково гідрованих піримідо [2, 1-b] тіазинів …

Recent progress in the synthesis of pyrimidothiazines

BF Abdel-Wahab, HA Mohamed - Phosphorus, Sulfur, and Silicon …, 2017 - Taylor & Francis
This review deals with the methods for the synthesis of various bicyclic pyrimidothiazines
which are not annelated with other cycles. Syntheses of pyrimido [2, 1-b]-, pyrimido [4, 5-b] …

[PDF][PDF] A Convenient Route for Synthesis and Antimicrobial Evaluation of Bis (diimino Benzothiazolo Pyrimido Pyrimidines)

BD Kalyankar, PN Ubale, SP Vartale - Oriental Journal of Chemistry, 2014 - Citeseer
Guanidine hydrochloride (1) on treatment with bis (methylthio) methylene malononitrile (2) in
N, N-dimethyl formamide (DMF) and catalytic amount of anhydrous potassium carbonate …