NCCN Guidelines® insights: Head and neck cancers, version 1.2022: Featured updates to the NCCN guidelines

JJ Caudell, ML Gillison, E Maghami, S Spencer… - Journal of the National …, 2022 - jnccn.org
The NCCN Guidelines for Head and Neck Cancers address tumors arising in the oral cavity
(including mucosal lip), pharynx, larynx, and paranasal sinuses. Occult primary cancer …

Evaluation of substantial reduction in elective radiotherapy dose and field in patients with human papillomavirus–associated oropharyngeal carcinoma treated with …

CJ Tsai, SM McBride, N Riaz, JJ Kang… - JAMA …, 2022 - jamanetwork.com
Importance Several de-escalation strategies for human papillomavirus (HPV)–associated
oropharyngeal carcinoma (OPC) have focused on deintensifying gross disease treatment …

Dose and volume de-escalation of radiotherapy in head and neck cancer

MJ García-Anaya, S Segado-Guillot… - Critical Reviews in …, 2023 - Elsevier
Radiotherapy plays a key role in the treatment of head and neck cancer. However,
irradiation of the head and neck region is associated with high rates of acute and chronic …

The metabolic footprint of systemic effects in the blood caused by radiotherapy and inflammatory conditions: a systematic review

K Jelonek, K Mrowiec, D Gabryś, P Widłak - Metabolites, 2023 - mdpi.com
Response to radiotherapy (RT) includes tissue toxicity, which may involve inflammatory
reactions. We aimed to compare changes in metabolic patterns induced at the systemic level …

Prevalence and distribution of cervical lymph node metastases in HPV-positive and HPV-negative oropharyngeal squamous cell carcinoma

L Bauwens, A Baltres, DJ Fiani, P Zrounba… - Radiotherapy and …, 2021 - Elsevier
Objective In oropharyngeal squamous cell carcinoma (OP-SCC), the prevalence and
distribution of clinical and pathological lymph node metastasis in the neck have been …

Prospective phase 2 study of radiation therapy dose and volume de-escalation for elective neck treatment of oropharyngeal and laryngeal cancer

DJ Sher, NL Pham, JL Shah, N Sen, KA Williams… - International Journal of …, 2021 - Elsevier
Purpose The required elective nodal dose and volumes for head and neck intensity
modulated radiation therapy have largely been extrapolated from conventional radiation …

High recurrence for HPV-positive oropharyngeal cancer with neoadjuvant radiation therapy to gross disease plus immunotherapy: analysis from a prospective phase …

TM Ma, DJ Wong, W Chai-Ho, A Mendelsohn… - International Journal of …, 2023 - Elsevier
Results Between September 2019 and March 2021, 19 patients (6 phase I and 13 phase II)
were enrolled (Fig. E3) and received protocol therapy as the study met criteria to proceed to …

Patterns and distribution of regional nodal involvement and recurrence in a surgically treated oropharyngeal squamous cell carcinoma cohort at a tertiary center

CN Abdel-Halim, TJ O'Byrne, JP Graves, CO Akpala… - Oral Oncology, 2023 - Elsevier
Objectives To investigate and describe the patterns of regional metastases and recurrences
after surgical treatment of oropharyngeal squamous cell cancer (OPSCC). Materials and …

Human papillomavirus-related non-metastatic oropharyngeal carcinoma: current local treatment options and future perspectives

M Svajdova, P Dubinsky, T Kazda, B Jeremic - Cancers, 2022 - mdpi.com
Simple Summary Current options for the curative treatment of the non-metastatic
oropharyngeal carcinoma associated with human papillomavirus include minimally-invasive …

[HTML][HTML] Individual elective lymph node irradiation for the reduction of complications in head and neck cancer patients (iNode): A phase-I feasibility trial protocol

FCJ Reinders, M de Ridder, PAH Doornaert… - Clinical and translational …, 2023 - Elsevier
Introduction The long-term complication rate in head-and-neck squamous cell carcinoma
(HNSCC) patients caused by radiotherapy (RT) can be decreased by restricting elective …