Metastasis involves the spread of cancer cells from the primary tumor to surrounding tissues
and to distant organs and is the primary cause of cancer morbidity and mortality. In order to …

Cell-in-cell structures are reported in numerous cancers, and their presence is an indicator
for poor prognosis. Mechanistic studies have identified how cancer cells manage to ingest …

Epithelial cells require attachment to extracellular matrix (ECM) to suppress an apoptotic cell
death program termed anoikis. Here we describe a nonapoptotic cell death program in …

Patients with breast cancer often develop malignant regrowth of residual drug-resistant
dormant tumor cells years after primary treatment, a process defined as cancer relapse …

For decades, authors have described unusual cell structures, referred to as cell-in-cell
structures, in which whole cells are found in the cytoplasm of other cells. One well …

Entosis is a form of epithelial cell cannibalism that is prevalent in human cancer, typically
triggered by loss of matrix adhesion. Here, we report an alternative mechanism for entosis in …

Detachment is the initial and critical step for cancer metastasis. Only the cells that survive
from detachment can develop metastases. Following the disruption of cell–extracellular …

Abstract Cell-in-cell (CIC) structures are commonly seen in tumours. Their biological
significance remains unclear, although they have been associated with more aggressive …

A phenomenon known for over 100 years named “cell-in-cell”(CIC) is now undergoing its
renaissance, mostly due to modern cell visualization techniques. It is no longer an esoteric …

Background A shift from respiration to fermentation is a common metabolic hallmark of
cancer cells. As a result, glucose and glutamine become the prime fuels for driving the …