RNA molecules start assembling into ribonucleoprotein (RNP) complexes during
transcription. Dynamic RNP assembly, largely directed by cis-acting elements on the RNA …

Production of sperm and androgens is the main function of the testis. This depends on
normal development of both testicular somatic cells and germ cells. A genetic program …

The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) long noncoding
RNA (lncRNA) has key roles in regulating transcription, splicing, tumorigenesis, etc. Its …

In mammals, gene silencing by the RNA-induced silencing complex (RISC) is a well-
understood cytoplasmic posttranscriptional gene regulatory mechanism. Here, we show that …

Mammalian spermatogenesis is sustained by mitotic germ cells with self-renewal potential
known as undifferentiated spermatogonia. Maintenance of undifferentiated spermatogonia …

TIA1 and TIAL1 encode a family of U-rich element mRNA-binding proteins ubiquitously
expressed and conserved in metazoans. Using PAR-CLIP, we determined that both proteins …

Translation efficiency can be affected by mRNA stability and secondary structures, including
G-quadruplex structures (G4s). The highly conserved DEAH-box helicase DHX36/RHAU …

Multiple RNA pathways are required to produce functional sperm. Here, we review RNA post-
transcriptional regulation during spermatogenesis with particular emphasis on the role of …

Maintaining cell fate relies on robust mechanisms that prevent the differentiation of specified
cells into other cell types. This is especially critical during embryogenesis, when extensive …

Due to the limitations of autologous chimeric antigen receptor (CAR)-T cells, alternative
sources of cellular immunotherapy, including CAR macrophages, are emerging for solid …