Cell surface receptors are important proteins that mediate communication between the cells
and their outside environment, and also play essential roles in the control of a wide variety of …

B-cell receptor (BCR) is a B cell hallmark surface complex regulating multiple cellular
processes in normal as well as malignant B cells. Igα (CD79a)/Igβ (CD79b) are essential …

As new generations of targeted therapies emerge and tumor genome sequencing discovers
increasingly comprehensive mutation repertoires, the functional relationships of mutations to …

The transcription factor Meis1 drives myeloid leukemogenesis in the context of Hox gene
overexpression but is currently considered undruggable. We therefore investigated whether …

Burkitt lymphoma (BL) is an aggressive lymphoma type that is currently treated by intensive
chemoimmunotherapy. Despite the favorable clinical outcome for most patients with BL …

The BCR consists of surface-bound Ig and a heterodimeric signaling unit comprised of
CD79A and CD79B. Upon cognate Ag recognition, the receptor initiates important signals …

Diffuse large B-cell lymphoma (DLBCL) can be subdivided into the activated B-cell (ABC)
and germinal center B cell–like (GCB) subtypes. Self-antigen engagement of B-cell …

Myristoylation, the N-terminal modification of proteins with the fatty acid myristate, is critical
for membrane targeting and cell signaling. Because cancer cells often have increased N …

Epstein–Barr virus (EBV) infects human B cells and reprograms them to allow virus
replication and persistence. One key viral factor in this process is latent membrane protein …

Lung cancer is the leading cause of cancer-related deaths worldwide. Fibroblast growth
factor receptor 1 (FGFR1) gene amplification is one of the most prominent and potentially …