The multi-factorial nature of clinical multidrug resistance in cancer

YG Assaraf, A Brozovic, AC Gonçalves… - Drug resistance …, 2019 - Elsevier
Curative cancer therapy remains a major challenge particularly in cancers displaying
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …

Novel nanomedicines to overcome cancer multidrug resistance

Z Su, S Dong, SC Zhao, K Liu, Y Tan, X Jiang… - Drug Resistance …, 2021 - Elsevier
Chemotherapy remains a powerful tool to eliminate malignant cells. However, the efficacy of
chemotherapy is compromised by the frequent emergence of intrinsic and acquired …

[HTML][HTML] A new threat from an old enemy: Re‑emergence of coronavirus

AO Docea, A Tsatsakis… - International …, 2020 - spandidos-publications.com
The new outbreak of coronavirus from December 2019 has brought attention to an old viral
enemy and has raised concerns as to the ability of current protection measures and the …

Consensus guidelines for the use and interpretation of angiogenesis assays

P Nowak-Sliwinska, K Alitalo, E Allen, A Anisimov… - Angiogenesis, 2018 - Springer
The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …

FDA approved drugs with pharmacotherapeutic potential for SARS-CoV-2 (COVID-19) therapy

S Drożdżal, J Rosik, K Lechowicz, F Machaj… - Drug resistance …, 2020 - Elsevier
In December 2019, a novel SARS-CoV-2 coronavirus emerged, causing an outbreak of life-
threatening pneumonia in the Hubei province, China, and has now spread worldwide …

Biological and pharmacological roles of m6A modifications in cancer drug resistance

Z Liu, H Zou, Q Dang, H Xu, L Liu, Y Zhang, J Lv, H Li… - Molecular Cancer, 2022 - Springer
Cancer drug resistance represents the main obstacle in cancer treatment. Drug-resistant
cancers exhibit complex molecular mechanisms to hit back therapy under pharmacological …

Surmounting cancer drug resistance: New insights from the perspective of N6-methyladenosine RNA modification

B Li, J Jiang, YG Assaraf, H Xiao, ZS Chen… - Drug resistance …, 2020 - Elsevier
Despite the development of targeted therapy, drug resistance remains a primary hindrance
to curative treatment of various cancers. Among several novel approaches to overcome drug …

Lysosomes as mediators of drug resistance in cancer

B Zhitomirsky, YG Assaraf - Drug Resistance Updates, 2016 - Elsevier
Drug resistance remains a leading cause of chemotherapeutic treatment failure and cancer-
related mortality. While some mechanisms of anticancer drug resistance have been well …

The chicken chorioallantoic membrane model in biology, medicine and bioengineering

P Nowak-Sliwinska, T Segura, ML Iruela-Arispe - Angiogenesis, 2014 - Springer
The chicken chorioallantoic membrane (CAM) is a simple, highly vascularized
extraembryonic membrane, which performs multiple functions during embryonic …

FGFR-TKI resistance in cancer: current status and perspectives

S Yue, Y Li, X Chen, J Wang, M Li, Y Chen… - Journal of hematology & …, 2021 - Springer
Fibroblast growth factor receptors (FGFRs) play key roles in promoting the proliferation,
differentiation, and migration of cancer cell. Inactivation of FGFRs by tyrosine kinase …