The NF-κB (nuclear factor κ-light-chain-enhancer of activated B cells) transcription factor
family is a pleiotropic regulator of many cellular signaling pathways, providing a mechanism …

Sepsis is a life-threatening clinical condition caused by a dysregulated host response to
infection. Sepsis-associated encephalopathy (SAE) is a common but poorly understood …

Abstract Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by
endothelial cells. It acts through two types of receptors: ETA and ETB. Apart from a …

In CKD, uremic solutes may induce endothelial dysfunction, inflammation, and oxidative
stress, leading to increased cardiovascular risk. We investigated whether the uremic solute …

Background The NOD-, LRR-and pyrin domain-containing protein 3 (NLRP3) inflammasome
has been identified as an important mediator of blood–brain-barrier disruption in sepsis …

Diabetic cardiomyopathy (DCM) is a myocardial disease independent of other
cardiovascular diseases, such as coronary heart disease, hypertension, etc. Lipotoxicity is …

Blood-brain barrier disruption occurs in the early stages of Alzheimer's disease. Recent
studies indicate a link between blood-brain barrier dysfunction and cognitive decline and …

Introduction 2.1. Tissue Factor (TF)-dependent activation of coagulation system 2.2.
Endothelial cells (ECs) directed Hemostasis 2.3. Virus life cycle 2.4. TLRs expression …

Abstract Endothelin-1 (ET-1) is involved in the regulation of a myriad of processes highly
relevant for physical and mental well-being; female and male health; in the modulation of …

Edible berries have a broad spectrum of biomedical functions, including improving immune
responses and reducing risk for chronic diseases. In this study, the anti-inflammatory …