The airway epithelium acts as a frontline defense against respiratory viruses, not only as a
physical barrier and through the mucociliary apparatus but also through its immunological …

Interferons (IFNs) were discovered as cytokines induced during and protecting from viral
infection. They have been documented to play essential roles in numerous physiological …

HOTAIR is a long intervening non-coding RNA (lincRNA) that associates with the Polycomb
Repressive Complex 2 (PRC2) and overexpression is correlated with poor survival for …

Hepatitis C virus (HCV) infects 3% of the world's population. Treatment of chronic HCV
consists of a combination of PEGylated interferon-α (PEG-IFN-α) and ribavirin (RBV). To …

BACKGROUND & AIMS: Hepatitis C virus (HCV) induces chronic infection in 50% to 80% of
infected persons; approximately 50% of these do not respond to therapy. We performed a …

Polyinosinic: polycytidylic acid (poly IC), a double-stranded RNA, is an effective adjuvant in
vivo. IFN-λs (also termed IL-28/29) are potent immunomodulatory and antiviral cytokines. We …

TLR repertoire and in vitro responsiveness of blood classical DC subsets. Human blood
DCs encompass pDCs and two subsets of mDCs: CD1c+ mDCs and CD141+ mDCs. The …

BACKGROUND & AIMS: A single nucleotide polymorphism (rs12979860 C/T) 3kb upstream
of the interleukin 28B (IL-28B) gene was shown to be associated with hepatitis C clearance …

Intracellular pathogens such as Listeria monocytogenes subvert cellular functions through
the interaction of bacterial effectors with host components. Here we found that a secreted …

Abstract The Coronavirus disease 2019 (COVID-19) pandemic is caused by the severe
acute respiratory syndrome 2 coronavirus (SARS-CoV-2), remaining a global health crisis …