The genomes of prokaryotes and eukaryotic organelles are usually circular as are most
plasmids and viral genomes. In contrast, the nuclear genomes of eukaryotes are organized …

Eukaryotic genomes are highly complex and divided into linear chromosomes that require
end protection from unwarranted fusions, recombination, and degradation in order to …

The lengths of human telomeres, which protect chromosome ends from degradation and
end fusions,, are crucial determinants of cell lifespan. During embryogenesis and in cancer …

Eukaryotic DNA is bound and interpreted by numerous protein complexes in the context of
chromatin. A description of the full set of proteins that regulate specific loci is critical to …

Summary Budding yeast Cdc13, Stn1, and Ten1 form the CST complex to protect telomeres
from lethal DNA degradation. It remains unknown whether similar complexes are conserved …

Orthologs of the yeast telomere protein Stn1 are present in plants, but other components of
the Cdc13/Stn1/Ten1 (CST) complex have only been found in fungi. Here we report the …

The telomeres that cap the ends of eukaryotic chromosomes serve a dual role in protecting
the chromosome ends and in intracellular signaling for regulating cell proliferation. A …

The maintenance of genomic stability relies on the coordinated action of a number of cellular
processes, including activation of the DNA-damage checkpoint, DNA replication, DNA …

What really defines a telomere? Telomere literally is an amalgamation of the Greek words
“telos,” meaning end, and “mer,” meaning part. In practice, it refers to the extremities of linear …

Telomeres consist of an elaborate, higher-order DNA architecture, and a suite of proteins
that provide protection for the chromosome terminus by blocking inappropriate …