Idiopathic or “unexplained” infertility represents as many as 30% of infertility cases
worldwide. Conception, implantation, and term delivery of developmentally healthy infants …

Accurate chromosome segregation requires the perfect spatiotemporal rearrangement of the
cellular cytoskeleton. Isolated more than two decades ago from Drosophila, Aurora A is a …

The Aurora protein kinases are well-established regulators of spindle building and
chromosome segregation in mitotic and meiotic cells. In mouse oocytes, there is significant …

A hallmark of advanced maternal age is a significant increase in meiotic chromosome
segregation errors, resulting in early miscarriages and congenital disorders. These errors …

Precise control of chromosome dynamics during meiosis is critical for fertility. A gametocyte
undergoing meiosis coordinates formation of the synaptonemal complex (SC) to promote …

The purpose of meiosis is to generate developmentally competent, haploid gametes with the
correct number of chromosomes. For reasons not completely understood, female meiosis is …

Long non-coding RNAs (lncRNAs) have been the subject of numerous studies over the past
decade. First thought to come from aberrant transcriptional events, lncRNAs are now …

Homologous chromosome segregation during meiosis I (MI) in mammalian oocytes is
carried out by the acentrosomal MI spindles. Whereas studies in human oocytes identified …

Human Perrault syndrome (PRLTS) is autosomal, recessively inherited, and characterized
by ovarian insufficiency with hearing loss. Among the genetic causes are mutations of matrix …

Cell division requires the regulation of karyokinesis and cytokinesis, which includes an
essential role of the achromatic spindle. Although the functions of centrosomes are well …