Adaptive designs are increasingly developed and used to improve all phases of clinical
trials and in biomedical studies in various ways to address different statistical issues. We first …

The design of sequential experiments and, in particular, randomised controlled trials
involves a trade-off between operational characteristics such as statistical power, estimation …

Response-adaptive randomization designs are becoming increasingly popular in clinical
trial practice. In this paper, we present RARtool, a user interface software developed in …

A class of optimal covariate-adjusted response adaptive procedures is developed for phase
III clinical trials when the treatment response is a survival time and there is random …

We consider optimal design problems for dose-finding studies with censored Weibull time-to-
event outcomes. Locally D-optimal designs are investigated for a quadratic dose–response …

A randomized, placebo-controlled, double-masked, equal-allocation clinical trial can be
viewed as an exemplary research design to obtain generalizable results on the treatment …

In many randomized controlled trials, treatment groups are of equal size, but this is not
necessarily the best choice. This paper provides a methodology to calculate optimal …

Response–adaptive treatment allocation procedures are sequentially adaptive schemes that
use past treatment assignments and patients' responses to select future treatment …

Klinik Araştırmalarda Kullanılan Uyarlanabilir (Adaptif) Tasarımlar ve Uygulamaları Amaç:
Bu çalışmanın amacı, klinik araştırmalarda uygulanan adaptif tasarımların incelenmesi …

An allocation function, invariant under monotonic transformation, is proposed in the context
of multi-arm clinical trials for a class of continuous response distributions. The aim is to skew …