Pancreatic cancer has an incidence that almost matches its mortality. Only a small number of
risk factors and 33 susceptibility loci have been identified. so Moreover, the relative rarity of …

Genes carrying high‐penetrance germline mutations may also be associated with cancer
susceptibility through common low‐penetrance genetic variants. To increase the knowledge …

Introduction: Pancreatic cancer remains among the top five causes of cancer-related
mortality. Only 18% to 20% of patients present with early-stage, potentially curable disease …

Introduction Pancreatic ductal adenocarcinoma (PDAC) is lethal due to its late diagnosis
and lack of successful treatments. A possible strategy to reduce its death burden is …

Simple Summary The available chemotherapeutic regimens for metastatic pancreatic ductal
adenocarcinoma (mPDAC) in Romania include FOLFIRINOX (FFX), gemcitabine-based …

Coding sequence variants comprise a small fraction of the germline genetic variability of the
human genome. However, they often cause deleterious change in protein function and are …

BACKGROUND Genetic tests are increasingly performed for the management of
unresectable pancreatic cancer. For genotyping aimed samples current guidelines …

Background Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy and is
unresponsive to conventional therapeutic modalities due to its high heterogeneity …

Objective: To identify and compare current modifiable and non-modifiable risk factors for
pancreatic cancer (PaCa) that may have potential application in PaCa risk stratification …

A lack of reliable early diagnostic tools represents a major challenge in the management of
pancreatic cancer (PCa), as the disease is often only identified after it reaches an advanced …