The tripartite motif containing (TRIM) proteins are a family of proteins that have been
implicated in many biological processes including cell differentiation, apoptosis …

Twenty-five years after the discovery of HIV as the cause of AIDS there is still no effective
vaccine and no cure for this disease. HIV susceptibility shows a substantial degree of …

TRIM5 is a restriction factor that blocks retrovirus infection soon after the virion core enters
the cell cytoplasm. Restriction activity is targeted to the virion core via recognition of the …

Type 1 interferon suppresses viral replication by upregulating the expression of interferon-
stimulated genes with diverse antiviral properties. The replication of human …

Previous studies identified clones of the U937 promonocytic cell line that were either
permissive or nonpermissive for human immunodeficiency virus type 1 (HIV-1) replication …

Toll-like, vitamin A and D receptors and other innate proteins participate in various immune
functions. We determined whether innate gene-sequence variations are associated with …

Type 1 interferons (IFNs) induce the expression of the tripartite interaction motif (TRIM)
family of E3 ligases, but the contribution of these antiviral factors to HIV pathogenesis is not …

Transplantation of allogenic hematopoietic stem and progenitor cells (HSPCs) with CC
chemokine receptor type 5 (CCR5) Δ32 genotype generates HIV-1 resistant immune cells …

HIV-1 is the single most important sexually transmitted disease in humans from a global
health perspective. Among human lentiviruses, HIV-1 M group has uniquely achieved …

We have observed significantly increased HIV infection in HIV infected macrophages in the
presence of cocaine that could be due to the downregulation of BST2 restriction factor in …