The gut microbiota–brain axis in behaviour and brain disorders

LH Morais, HL Schreiber IV… - Nature Reviews …, 2021 - nature.com
In a striking display of trans-kingdom symbiosis, gut bacteria cooperate with their animal
hosts to regulate the development and function of the immune, metabolic and nervous …

The gut-brain axis: is intestinal inflammation a silent driver of Parkinson's disease pathogenesis?

MC Houser, MG Tansey - NPJ Parkinson's disease, 2017 - nature.com
The state of the intestinal environment can have profound effects on the activity of the central
nervous system through the physiological contributions of the microbiota, regulation of …

Anti–tumor necrosis factor therapy and incidence of Parkinson disease among patients with inflammatory bowel disease

I Peter, M Dubinsky, S Bressman, A Park, C Lu… - JAMA …, 2018 - jamanetwork.com
Importance Despite established genetic and pathophysiologic links between inflammatory
bowel disease (IBD) and Parkinson disease (PD), clinical data supporting this association …

Vagotomy and Parkinson disease: A Swedish register–based matched-cohort study

B Liu, F Fang, NL Pedersen, A Tillander… - Neurology, 2017 - AAN Enterprises
Objective: To examine whether vagotomy decreases the risk of Parkinson disease (PD).
Methods: Using data from nationwide Swedish registers, we conducted a matched-cohort …

The vermiform appendix impacts the risk of developing Parkinson's disease

BA Killinger, Z Madaj, JW Sikora, N Rey… - Science translational …, 2018 - science.org
The pathogenesis of Parkinson's disease (PD) involves the accumulation of aggregated α-
synuclein, which has been suggested to begin in the gastrointestinal tract. Here, we …

The gut microbiota–brain axis in neurological disorder

H Ullah, S Arbab, Y Tian, C Liu, Y Chen… - Frontiers in …, 2023 - frontiersin.org
The gut microbiota (GM) plays an important role in the physiology and pathology of the host.
Microbiota communicate with different organs of the organism by synthesizing hormones …

Characterizing dysbiosis of gut microbiome in PD: evidence for overabundance of opportunistic pathogens

ZD Wallen, M Appah, MN Dean, CL Sesler… - npj Parkinson's …, 2020 - nature.com
In Parkinson's disease (PD), gastrointestinal features are common and often precede the
motor signs. Braak and colleagues proposed that PD may start in the gut, triggered by a …

The endotoxin hypothesis of Parkinson's disease

GC Brown, M Camacho… - Movement …, 2023 - Wiley Online Library
The endotoxin hypothesis of Parkinson's disease (PD) is the idea that lipopolysaccharide
(LPS) endotoxins contribute to the pathogenesis of this disorder. LPS endotoxins are found …

Gut–brain axis and the spread of α‐synuclein pathology: vagal highway or dead end?

DP Breen, GM Halliday, AE Lang - Movement disorders, 2019 - Wiley Online Library
Spread of α‐synuclein pathology from the peripheral to central nervous system may be an
important etiological factor in Parkinson's disease, although there are some unanswered …

Neuroinflammation and Parkinson's disease—From neurodegeneration to therapeutic opportunities

B Araújo, R Caridade-Silva, C Soares-Guedes… - Cells, 2022 - mdpi.com
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder
worldwide. Clinically, it is characterized by a progressive degeneration of dopaminergic …