Non-steroidal anti-inflammatory drugs (NSAIDs) are the competitive inhibitors of
cyclooxygenase (COX), the enzyme which mediates the bioconversion of arachidonic acid …

1, 4-Dihydropyridine (1, 4-DHP) is one of the foremost notable organic scaffolds with diverse
pharmaceutical applications. This study will highlight recent accomplishments in the …

Addressed herein, highly monodispersed PdRuNi nanoparticles furnished with graphene
oxide (PdRuNi@ GO NPs) were prepared as novel, stable, efficient and exceptionally …

Abstract Selective cyclooxygenase-2 (COX-2) inhibitors have exhibited notable medicinal
importance. In recent years, the discovery of new anti-inflammatory agents as selective COX …

Oxo-hexahydroquinoline (5-oxo-HHQ) represents a biologically attractive fused heterocyclic
core. Various synthetic analogs of 5-oxo-HHQ have been synthesized and assessed for …

Background: The emergence of drug-resistant viral strains has created the need for the
development of novel anti-HIV agents with a diverse structure that targets key enzymes in …

Cyclooxygenase-2 (COX-2) is a key-type enzyme playing a crucial role in cancer
development, making it a target of high interest for drug designers. In the last two decades …

A series of 26 selective COX-2 inhibitors which reported previously by our laboratory was
selected to generate three-dimensional quantitative structure activity relationship (3D …

The three-component Hantzsch condensation of various aryl aldehydes, dimedone, and
methyl 3-aminocrotonate was investigated in the presence of MCM-41-supported ZnNO 3 …

A simple mild, efficient, expeditious and straightforward synthetic methodology has been
established toward furnishing of therapeutically important structurally diverse multi …