Lyme disease in humans

JD Radolf, K Strle, JE Lemieux, F Strle - Current issues in molecular …, 2021 - mdpi.com
Lyme disease (Lyme borreliosis) is a tick-borne, zoonosis of adults and children caused by
genospecies of the Borrelia burgdorferi sensu lato complex. The ailment, widespread …

Lyme disease pathogenesis

J Coburn, B Garcia, LT Hu, MW Jewett… - Current issues in …, 2021 - mdpi.com
Lyme disease Borrelia are obligately parasitic, tick-transmitted, invasive, persistent bacterial
pathogens that cause disease in humans and non-reservoir vertebrates primarily through …

Development of an mRNA-lipid nanoparticle vaccine against Lyme disease

M Pine, G Arora, TM Hart, E Bettini, BT Gaudette… - Molecular Therapy, 2023 - cell.com
Lyme disease is the most common vector-borne infectious disease in the United States, in
part because a vaccine against it is not currently available for humans. We propose utilizing …

Whole genome sequencing of human Borrelia burgdorferi isolates reveals linked blocks of accessory genome elements located on plasmids and associated with …

JE Lemieux, W Huang, N Hill, T Cerar… - PLoS …, 2023 - journals.plos.org
Lyme disease is the most common vector-borne disease in North America and Europe. The
clinical manifestations of Lyme disease vary based on the genospecies of the infecting …

[HTML][HTML] Cutaneous Lyme borreliosis: guideline of the German dermatology society

H Hofmann, V Fingerle, KP Hunfeld… - GMS german medical …, 2017 - ncbi.nlm.nih.gov
This guideline of the German Dermatology Society primarily focuses on the diagnosis and
treatment of cutaneous manifestations of Lyme borreliosis. It has received consensus from …

Complement evasion by Lyme disease spirochetes

JT Skare, BL Garcia - Trends in microbiology, 2020 - cell.com
The complement system is an ancient arm of the innate immune system that plays important
roles in pathogen recognition and elimination. Upon activation by microbes, complement …

The Brilliance of Borrelia: Mechanisms of Host Immune Evasion by Lyme Disease-Causing Spirochetes

C Anderson, CA Brissette - Pathogens, 2021 - mdpi.com
Lyme disease (LD) has become the most common vector-borne illness in the northern
hemisphere. The causative agent, Borrelia burgdorferi sensu lato, is capable of establishing …

Interaction of the Lyme disease spirochete with its tick vector

MJ Caimano, D Drecktrah, F Kung… - Cellular …, 2016 - Wiley Online Library
Borrelia burgdorferi, the causative agent of Lyme disease (along with closely related
genospecies), is in the deeply branching spirochete phylum. The bacterium is maintained in …

Plasminogen-binding proteins as an evasion mechanism of the host's innate immunity in infectious diseases

DA Ayón-Núñez, G Fragoso, RJ Bobes… - Bioscience …, 2018 - portlandpress.com
Pathogens have developed particular strategies to infect and invade their hosts. Amongst
these strategies' figures the modulation of several components of the innate immune system …

Pathogenicity and virulence of Borrelia burgdorferi

M Strnad, N Rudenko, ROM Rego - Virulence, 2023 - Taylor & Francis
Infection with Borrelia burgdorferi often triggers pathophysiologic perturbations that are
further augmented by the inflammatory responses of the host, resulting in the severe clinical …