Tailored functionalized protein nanocarriers for cancer therapy: recent developments and prospects

MAA Abdelhamid, MR Ki, AAA El-Hafeez, RG Son… - Pharmaceutics, 2023 - mdpi.com
Recently, the potential use of nanoparticles for the targeted delivery of therapeutic and
diagnostic agents has garnered increased interest. Several nanoparticle drug delivery …

[HTML][HTML] Protein scaffolds in human clinics

O Cano-Garrido, N Serna, U Unzueta, E Parladé… - Biotechnology …, 2022 - Elsevier
Fundamental clinical areas such as drug delivery and regenerative medicine require
biocompatible materials as mechanically stable scaffolds or as nanoscale drug carriers …

Aptamer-based assembly systems for SARS-CoV-2 detection and therapeutics

Y Dong, J Wang, L Chen, H Chen, S Dang… - Chemical Society …, 2024 - pubs.rsc.org
Nucleic acid aptamers are oligonucleotide chains with molecular recognition properties.
Compared with antibodies, aptamers show advantages given that they are readily produced …

[HTML][HTML] High-precision targeting and destruction of cancer-associated PDGFR-β+ stromal fibroblasts through self-assembling, protein-only nanoparticles

E Voltà-Durán, L Alba-Castellón, N Serna, I Casanova… - Acta biomaterialia, 2023 - Elsevier
The need for more effective and precision medicines for cancer has pushed the exploration
of new materials appropriate for drug delivery and imaging, and alternative receptors for …

The Diphtheria toxin translocation domain impairs receptor selectivity in cancer cell-targeted protein nanoparticles

E Voltà-Durán, JM Sánchez, E Parladé, N Serna… - Pharmaceutics, 2022 - mdpi.com
Protein-based materials intended as nanostructured drugs or drug carriers are progressively
gaining interest in nanomedicine, since their structure, assembly and cellular interactivity …

[HTML][HTML] Paradoxical cell targeting of calreticulin-empowered, protein-only nanoparticles

E Parladé, A García-Leon, E Voltà-Durán… - European Journal of …, 2024 - Elsevier
Surface-exposed calreticulin (CRT) serves as a crucial cell damage-associated molecular
pattern for immunogenic apoptosis, by generating an “eat me” signal to macrophages …

Site-directed cysteine coupling of disulfide-containing non-antibody carrier proteins (THIOCAPs)

A Rueda, JI Mendoza, L Alba-Castellon… - Science China …, 2023 - Springer
The development of a new generation of non-antibody protein drug delivery systems
requires site-directed conjugation strategies to produce homogeneous, reproducible and …

Nanoconjugate formulations for enhanced drug delivery

E Oner, M Ilhan, HE Gultekin, M Karpuz - Advanced and Modern …, 2023 - Elsevier
Nanoconjugate is the nanosized drug delivery system, which consists of a drug molecule or
a drug-loaded carrier attached to a moiety covalently or noncovalently. There is a growing …

Syntheses of poly (lactic acid) s and their block copolymers for drug delivery applications

LW Oktavia, D Bégué, PT Campana… - Polymer …, 2023 - Wiley Online Library
Since the advent of supporting matrices for biological applications, many types of drugs
have been administered via various forms of conventional drug delivery preparations, such …