Bioactive peptides: Synthesis, sources, applications, and proposed mechanisms of action

M Akbarian, A Khani, S Eghbalpour… - International journal of …, 2022 - mdpi.com
Bioactive peptides are a group of biological molecules that are normally buried in the
structure of parent proteins and become active after the cleavage of the proteins. Another …

Bioactivities, applications, safety, and health benefits of bioactive peptides from food and by-products: A review

AA Zaky, J Simal-Gandara, JB Eun, JH Shim… - Frontiers in …, 2022 - frontiersin.org
Bioactive peptides generated from food proteins have great potential as functional foods and
nutraceuticals. Bioactive peptides possess several significant functions, such as …

Drug development, Brazilian biodiversity and political choices: Where are we heading?

PMP Ferreira, DDR Arcanjo… - Journal of Toxicology and …, 2023 - Taylor & Francis
The aim of this review was to (i) acknowledge structural advantages of natural products
(NPs) for designing therapeutic drugs;(ii) emphasize how wildlife conservation is socially …

A review on bioactive peptides: Physiological functions, bioavailability and safety

D Bhandari, S Rafiq, Y Gat, P Gat, R Waghmare… - International Journal of …, 2020 - Springer
Bioactive peptides can be defined as isolated small fragments of proteins which provide
some physiological health benefits. They act as potential modifiers reducing the risk of many …

Migrastatics—anti-metastatic and anti-invasion drugs: promises and challenges

A Gandalovičová, D Rosel, M Fernandes, P Veselý… - Trends in cancer, 2017 - cell.com
In solid cancers, invasion and metastasis account for more than 90% of mortality. However,
in the current armory of anticancer therapies, a specific category of anti-invasion and …

Bioactive peptides and depsipeptides with anticancer potential: Sources from marine animals

GM Suarez-Jimenez, A Burgos-Hernandez… - Marine drugs, 2012 - mdpi.com
Biologically active compounds with different modes of action, such as, antiproliferative,
antioxidant, antimicrotubule, have been isolated from marine sources, specifically algae and …

Current scenario of peptide-based drugs: the key roles of cationic antitumor and antiviral peptides

KCL Mulder, LA Lima, VJ Miranda, SC Dias… - Frontiers in …, 2013 - frontiersin.org
Cationic antimicrobial peptides (AMPs) and host defense peptides (HDPs) show vast
potential as peptide-based drugs. Great effort has been made in order to exploit their …

TRPM7 promotes the epithelial–mesenchymal transition in ovarian cancer through the calcium-related PI3K/AKT oncogenic signaling

L Liu, N Wu, Y Wang, X Zhang, B Xia, J Tang… - Journal of Experimental …, 2019 - Springer
Background The epithelial-mesenchymal transition (EMT) is crucial for metastasis and
positively regulated by calcium-related signaling. The melastatin-related transient receptor …

Anticancer potential of bioactive peptides from animal sources

L Wang, C Dong, X Li, W Han, X Su - Oncology reports, 2017 - spandidos-publications.com
Cancer is the most common cause of human death worldwide. Conventional anticancer
therapies, including chemotherapy and radiation, are associated with severe side effects …

Biotechnological applications of bioactive peptides from marine sources

D Giordano, M Costantini, D Coppola… - Advances in microbial …, 2018 - Elsevier
This review is an overview on marine bioactive peptides with promising activities for the
development of alternative drugs to fight human pathologies. In particular, we focus on …