Reappraisal of ventilator-free days in critical care research

N Yehya, MO Harhay, MAQ Curley… - American journal of …, 2019 - atsjournals.org
Ventilator-free days (VFDs) are a commonly reported composite outcome measure in acute
respiratory distress syndrome trials. VFDs combine survival and duration of ventilation in a …

Mechanical ventilation: state of the art

T Pham, LJ Brochard, AS Slutsky - Mayo Clinic Proceedings, 2017 - Elsevier
Mechanical ventilation is the most used short-term life support technique worldwide and is
applied daily for a diverse spectrum of indications, from scheduled surgical procedures to …

Effect of dexamethasone on days alive and ventilator-free in patients with moderate or severe acute respiratory distress syndrome and COVID-19: the CoDEX …

BM Tomazini, IS Maia, AB Cavalcanti, O Berwanger… - Jama, 2020 - jamanetwork.com
Importance Acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019
(COVID-19) is associated with substantial mortality and use of health care resources …

Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study

T Pham, L Heunks, G Bellani, F Madotto… - The Lancet …, 2023 - thelancet.com
Background Current management practices and outcomes in weaning from invasive
mechanical ventilation are poorly understood. We aimed to describe the epidemiology …

[HTML][HTML] Spontaneous-breathing trials with pressure-support ventilation or a T-piece

AW Thille, A Gacouin, R Coudroy… - … England Journal of …, 2022 - Mass Medical Soc
Background Spontaneous-breathing trials can be performed with the use of either pressure-
support ventilation (PSV) or a T-piece. Whether PSV trials may result in a shorter time to …

Mechanical ventilation–induced diaphragm atrophy strongly impacts clinical outcomes

EC Goligher, M Dres, E Fan, GD Rubenfeld… - American journal of …, 2018 - atsjournals.org
Rationale: Diaphragm dysfunction worsens outcomes in mechanically ventilated patients,
but the clinical impact of potentially preventable changes in diaphragm structure and …

Ventilator weaning and discontinuation practices for critically ill patients

KEA Burns, L Rizvi, DJ Cook, G Lebovic, P Dodek… - Jama, 2021 - jamanetwork.com
Importance Although most critically ill patients receive invasive mechanical ventilation (IMV),
few studies have characterized how IMV is discontinued in practice. Objective To describe …

Extubation in neurocritical care patients: the ENIO international prospective study

R Cinotti, JC Mijangos, P Pelosi, M Haenggi… - Intensive care …, 2022 - Springer
Purpose Neurocritical care patients receive prolonged invasive mechanical ventilation
(IMV), but there is poor specific information in this high-risk population about the liberation …

Prediction of extubation outcome in critically ill patients: a systematic review and meta-analysis

F Torrini, S Gendreau, J Morel, G Carteaux, AW Thille… - Critical Care, 2021 - Springer
Background Extubation failure is an important issue in ventilated patients and its risk factors
remain a matter of research. We conducted a systematic review and meta-analysis to …

Inability of diaphragm ultrasound to predict extubation failure: a multicenter study

E Vivier, M Muller, JB Putegnat, J Steyer, S Barrau… - Chest, 2019 - Elsevier
Background Diaphragmatic dysfunction may promote weaning difficulties in patients who
are mechanically ventilated. Objective The goal of this study was to assess whether …